Use of Batch Mixing To Investigate the Continuous Solvent-Free Mechanical Synthesis of OLED Materials by Twin-Screw Extrusion (TSE)
Use of Batch Mixing To Investigate the Continuous Solvent-Free Mechanical Synthesis of OLED Materials by Twin-Screw Extrusion (TSE)
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DOI：
10.1021/acssuschemeng.7b02202
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发表时间：
2018-01
影响因子：
8.4
通讯作者：
Deborah E. Crawford;S. James;T. McNally
中科院分区：
文献类型：
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作者：
Deborah E. Crawford;S. James;T. McNally
机械化学合成有可能改变化学的进行方式，特别是在去除或大大减少对溶剂的需求方面。最近，它已被证明，机械力化学可以进行连续和大规模通过使用双螺杆挤出（TSE）。TSE已成功应用于共晶、金属有机骨架（MOFs）、深共熔溶剂（DES）、金属配合物和有机缩合反应的合成。然而，虽然TSE提供了一种将机械化学合成发展成连续、大批量生产工艺的途径，但目前对如何最佳优化所涉及的各种工艺参数知之甚少。在这里，我们研究了使用的间歇式混合器，已在聚合物加工中使用，以优化通过挤出进行的机械化学反应。特别是8-羟基喹啉（Hq）和锌或铝的金属乙酸盐之间的反应，以...
Mechanochemical synthesis has the potential to change the way in which chemistry is conducted, particularly with regard to removing or dramatically reducing the need for solvents. Recently, it has been demonstrated that mechanochemistry can be carried out continuously and on large scale through the use of twin-screw extrusion (TSE). TSE has successfully been applied to the synthesis of cocrystals, metal organic frameworks (MOFs), deep eutectic solvents (DESs), metal complexes, and organic condensation reactions. However, while TSE provides a route for mechanochemical synthesis to be developed into a continuous, high-volume manufacturing process, little is currently understood about how to best optimize the various process parameters involved. Herein, we investigate the use of a batch mixer that has been previously used in polymer processing, to optimize mechanochemical reactions performed by extrusion. In particular, reactions between 8-hydroxyquinoline (Hq) and metal acetate salts of zinc or aluminum to ...