Lymphoma‐ and leukemia‐associated cutaneous atypical CD30+ T‐cell reactions
Lymphoma‐ and leukemia‐associated cutaneous atypical CD30+ T‐cell reactions
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淋巴瘤和白血病相关皮肤非典型 CD30+ T 细胞反应
DOI：
10.1034/j.1600-0560.2000.027005249.x
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发表时间：
2000
影响因子：
1.7
通讯作者：
L. Duncan
中科院分区：
文献类型：
--
作者：
L. Su;L. Duncan
皮肤 CD30+ 淋巴浸润在细胞学上表现出非典型性，当其发生在接受其他原发性血液恶性肿瘤治疗的患者中时，有时可能会被误解为复发性疾病。我们最近遇到了两个这样的案例并介绍了我们的发现。一名 B 细胞淋巴瘤患者和另一名髓系白血病患者在化疗后出现皮疹，组织学上显示高度非典型的血管周围淋巴细胞，类似于复发性疾病。通过免疫组织化学检测，这两种情况下的淋巴细胞均为 CD30+ T 细胞。皮损自然消退，未再复发。由于一例最初被误解为复发性白血病，我们得出结论，对于原发性血液系统恶性肿瘤患者的非典型皮肤淋巴浸润，应进行密切的临床相关性和免疫表型确认。我们讨论这种情况下非典型 CD30+ 浸润的鉴别诊断，包括复发性淋巴瘤或粒细胞白血病、原发性皮肤间变性大细胞淋巴瘤 (ALCL)、淋巴瘤样丘疹病 (LyP)、卡马西平诱导的 CD30+ 假性淋巴瘤、病毒感染和淋巴细胞恢复的非典型疹。
Cutaneous CD30+ lymphoid infiltrates appear cytologically atypical and occasionally may be misinterpreted as recurrent disease when they occur in patients treated for other primary hematologic malignancies. We recently encountered two such cases and present our findings. One patient with B‐cell lymphoma and another with myeloid leukemia developed cutaneous eruptions after chemotherapy displaying highly atypical perivascular lymphoid cells on histology that mimicked recurrent disease. In both cases, the lymphocytes were CD30+ T cells by immunohistochemistry. The skin lesions spontaneously resolved and have not recurred. Because one case was initially misinterpreted as recurrent leukemia, we conclude that close clinical correlation and immunophenotypic confirmation should be done for atypical cutaneous lymphoid infiltrates in patients with primary hematologic malignancies. We discuss the differential diagnosis of atypical CD30+ infiltrates in this setting, which include recurrent lymphoma or myeloid leukemia, primary cutaneous anaplastic large cell lymphoma (ALCL), lymphomatoid papulosis (LyP), carbamazepine‐induced CD30+ pseudolymphoma, viral infection and an atypical eruption of lymphocyte recovery.
间变性大细胞 Ki-1 恶性淋巴瘤。
影响因子：
--
作者：
Kinney,MC;Greer,JP;Glick,AD;Salhany,KE;Collins,RD
通讯作者：
Collins,RD
CD30 原发性皮肤淋巴增殖性疾病和霍奇金病中 t(2;5) (p23;q35) 易位的分析。
影响因子：
2.6
作者：
Wood,GS
通讯作者：
Wood,GS
蕈样肉芽肿的转化：T细胞受体β基因分析表明斑块型蕈样肉芽肿和CD30大细胞淋巴瘤有共同的克隆起源。
DOI：
10.1111/1523-1747.ep12365416
发表时间：
1993
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Wood,GS;Bahler,DW;Hoppe,RT;Warnke,RA;Sklar,JL;Levy,R
通讯作者：
Levy,R