Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain.
Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain.
复制标题
对各种离子通道进行局部麻醉作用以减轻术后疼痛的新想法。
DOI：
10.1093/bja/aen101
复制
发表时间：
2008
影响因子：
9.8
通讯作者：
Strichartz,GR
中科院分区：
文献类型：
--
作者：
Strichartz,GR
本综述考虑了外周伤害性能量转导的离子通道，参与外周感觉神经元的脉冲启动和传播，以及参与脊髓背角突触前和突触后动作的离子通道，因为它们对局部麻醉剂敏感。尽管离体分离细胞和组织的实验结果支持假设的作用，但它们对体内作用的外推以及对围手术期和术后疼痛控制的影响在很大程度上是推测性的。
This review considers the ion channels that underlie transduction of nociceptive energies in the periphery, that are involved in impulse initiation and propagation in peripheral sensory neurones, and that participate in pre- and post-synaptic actions in the spinal cord dorsal horn, in light of their susceptibility to local anaesthetics. Although there are results from experiments on isolated cells and tissuesex vivothat support the hypothesized actions, their extrapolation to actionsin vivoand the consequences for peri- and postoperative pain control are largely speculative.