Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles
Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles
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DOI：
10.1021/ja053902e
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发表时间：
2005-09-21
影响因子：
15
通讯作者：
Discher, DE
中科院分区：
文献类型：
--
作者：
Geng, Y;Discher, DE
由可降解聚合物制成的球形胶束和纳米颗粒在治疗应用中引起了极大的兴趣，但降解引起的球形形态变化可能是微妙的，其机制/动力学似乎知之甚少。在这里，我们首次报道了由可降解共聚物聚（环氧乙烷）-嵌段聚己内酯自组装的巨大柔性蠕虫胶束的制备。这种蠕虫胶束在聚己内酯水解的作用下自发缩短成球形胶束，其机理和动力学与块状材料中发生的胶束不同。
Spherical micelles and nanoparticles made with degradable polymers have been of great interest for therapeutic application, but degradation-induced changes in a spherical morphology can be subtle and mechanism/kinetics appears poorly understood. Here, we report the first preparation of giant and flexible worm micelles self-assembled from degradable copolymer poly(ethylene oxide)-block-polycaprolactone. Such worm micelles spontaneously shorten to generate spherical micelles, triggered by polycaprolactone hydrolysis, with distinct mechanism and kinetics from that which occurs in bulk material.