ROLE OF RIGHT ATRIAL RECEPTORS IN THE CONTROL OF DRINKING IN THE RAT
ROLE OF RIGHT ATRIAL RECEPTORS IN THE CONTROL OF DRINKING IN THE RAT
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DOI：
10.1113/jphysiol.1984.sp015162
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发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
KAUFMAN, S
中科院分区：
文献类型：
--
作者：
KAUFMAN, S
在大鼠的上级腔静脉和右心房的交界处植入支架。球囊膨胀拉伸了静脉-心房交界处，但没有引起动脉或中心静脉血压的变化。充气气球衰减自发夜间饮水和饮水反应24小时禁水和s.c.异丙肾上腺素（10 μ g/kg体重）。当球囊在接近水之前即刻充盈时（注射后4 h），腹膜内高渗胶体（聚乙二醇20 M）后的水摄入几乎被消除。静脉注射高渗盐水（5 ml 2 M-NaCl/kg体重）后，球囊充盈对饮水没有影响。这些结果支持了心脏右侧的容量受体参与控制水摄入的假设。
Balloons were implanted at the junction of the superior vena cava and right atrium of the rat. Inflation of the balloon stretched the vein-atrial junction but did not cause a change in either arterial or central venous blood pressure. Inflating the balloon attenuated spontaneous night-time water intake and the drinking responses to 24 h water deprivation and s.c. isoprenaline (10 .mu.g/kg body wt). Water intake after i.p. hyperoncotic colloid (polyethylene glycol 20 M) was virtually abolished when the balloon was inflated immediately before giving access to water (4 h after injection). Inflating the balloon had no effect on drinking following i.v. hypertonic saline (5 ml 2 M-NaCl/kg body wt). These results support the hypothesis that volume receptors on the right side of the heart are involved in controlling water intake.