Rh(III)-catalyzed C-H activation/[4+3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones
Rh(III)-catalyzed C-H activation/[4+3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones
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Rh(III) 催化的 C-H 活化/[4 3] 苯甲酰胺和乙烯基类胡萝卜素的环加成：氮杂酮的简便合成
DOI：
10.1039/c3sc51777b
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发表时间：
2013-01-01
期刊：
影响因子：
8.4
通讯作者：
Wu, Qifan
中科院分区：
文献类型：
--
作者：
Cui, Sunliang;Zhang, Yan;Wu, Qifan
乙烯基类卡宾作为三碳组分用于Rh（III）催化的C-H活化/与苯甲酰胺的[4 + 3]环加成以获得氮杂卓酮。该方法具有原料简单、反应条件温和、转化效率高等特点。进行了动力学同位素效应研究，并提出了一个合理的机制。
Vinylcarbenoids are used as three-carbon components in Rh(III)-catalyzed C-H activation/[4 + 3] cycloaddition with benzamides to access azepinones. This transformation makes a feature of simple starting materials, mild reaction conditions and high efficiency. A kinetic isotope effect study was conducted and a plausible mechanism is proposed.