Population data and phylogenetic structure of 19 STR loci in Chinese Hui ethnic group residing in Yunnan province of China
Population data and phylogenetic structure of 19 STR loci in Chinese Hui ethnic group residing in Yunnan province of China
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云南回族19个STR基因座的群体数据及系统发育结构
DOI：
10.1016/j.legalmed.2022.102044
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lei Huang
中科院分区：
文献类型：
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作者：
Xiufeng Zhang;Yunrui Yang;Hongping Liu;Wu Zuo;Lei Huang
对535名云南回族健康个体19个常染色体STR基因座的等位基因频率分布和法医学统计参数进行了估计。在这些位点上共检测到236个等位基因，其等位基因频率在0.000935 ~ 0.527103之间。Penta E在回族人群中的信息量最大，而TPOX的信息量最小。经Bonferroni校正后，所有STR基因座均达到Hardy-Weinberg平衡。19个STR基因座的综合鉴别力和排除亲子关系的概率分别为0.999 999 999 999 999 999 984 47 16和0.999 999 988。此外，还根据遗传距离估算了云南回族与其他8个回族群体和25个已调查的中国其他地区回族群体的亲缘关系。结果表明，19个STR基因座具有高度多态性，适用于法医学个人识别和亲子鉴定。
Allele frequency distributions and statistical forensic parameters of 19 autosomal STR loci in a sample of 535 unrelated healthy Hui individuals from Yunnan province were estimated. A total of 236 alleles at these loci were identified and their corresponding allele frequencies ranged from 0.000935 to 0.527103. Penta E is the most informative in Hui population, whereas TPOX showed the lowest. All of the STR loci reached the Hardy-Weinberg equilibrium after Bonferroni correction. The combined discrimination power and probability of excluding paternity of the 19 STR loci were 0.999 999 999 999 999 999 999 984 47 16 and 0.999 999 988, respectively. Furthermore, the genetic relationship between the Yunnan Hui population and other 8 different Hui groups or 25 previously investigated groups residing in other areas of China were also estimated based on pairwise genetic distance. These results suggest that the 19 STR loci are highly polymorphic, which is suitable for forensic personal identification and paternity testing.