Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2 diabetes
Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2 diabetes
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DOI：
10.7326/0003-4819-131-1-199907060-00006
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发表时间：
1999-07-06
影响因子：
39.2
通讯作者：
Jansson, PA
中科院分区：
文献类型：
--
作者：
Axelsen, M;Smith, U;Jansson, PA
背景：餐后血脂清除能力受损是与胰岛素抵抗相关的动脉粥样硬化的特征。目的：评估糖尿病前期患者的胰岛素敏感性和餐后甘油三酯代谢。设计：横断面研究。地点：瑞典哥德堡的Sahlgrenska大学医院。参与者：13名健康、正常的甘油三酯血症男性，有两名一级亲属患有2型糖尿病，13名精心匹配的对照组，没有糖尿病遗传。测量：口服葡萄糖耐量试验，胰岛素敏感性(正血糖钳夹技术)，以及混合餐后的空腹和餐后甘油三酯水平。结果：2型糖尿病患者的亲属有胰岛素抵抗，但糖耐量正常。他们表现为餐后高甘油三酯血症，曲线下6h甘油三酯增量面积比对照组增加50%(P=0.037)。结论：这些健康男性2型糖尿病患者一级亲属存在胰岛素抵抗，尽管空腹甘油三酯水平正常，但仍存在餐后血脂不耐受。这些特征发生在没有糖耐量异常的情况下，与大血管病变的风险增加有关。
Background: Impaired ability to eliminate lipids in the postprandial state is an atherogenic trait associated with insulin resistance.Objective: To assess insulin sensitivity and postprandial triglyceride metabolism in prediabetic persons.Design: Cross-sectional study.Setting: Sahlgrenska University Hospital, Goteborg, Sweden.Participants: 13 healthy, normotriglyceridemic men with two first-degree relatives with type 2 diabetes and 13 carefully matched controls without known diabetes heredity.Measurements: Oral glucose tolerance test, insulin sensitivity (euglycemic clamp technique), and fasting and postprandial triglyceride levels after a mixed meal.Results: Relatives of persons with type 2 diabetes were insulin resistant but had normal glucose tolerance. They exhibited postprandial hypertriglyceridemia; the 6-hour triglyceride incremental area under the curve was 50% higher than that of the control group (P = 0.037).Conclusions: These healthy male first-degree relatives of patients with type 2 diabetes are insulin resistant and exhibit postprandial lipid intolerance despite having normal fasting triglyceride levels. These characteristics, which occur in the absence of glucose intolerance, are associated with an increased risk for macroangiopathy.