The Yale-Brown Obsessive Compulsive Scale. II. Validity.
The Yale-Brown Obsessive Compulsive Scale. II. Validity.
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DOI：
10.1001/archpsyc.1989.01810110054008
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发表时间：
1989-11
影响因子：
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通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
中科院分区：
文献类型：
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作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
耶鲁-布朗强迫症量表的开发设计和可靠性在其他地方已经描述过。我们关注的是耶鲁-布朗量表的有效性及其对变化的敏感性。在三个队列的强迫症患者（N = 81）的基线评级中检查收敛和判别效度。耶鲁-布朗量表总分与强迫症的三个独立指标中的两个显著相关，与伴有轻微继发性抑郁症状的强迫症患者的抑郁和焦虑指标弱相关。先前报道的42例强迫症患者的氟伏沙明安慰剂对照试验结果显示，耶鲁-布朗量表对药物引起的变化敏感，耶鲁-布朗量表评分的降低特别反映了强迫症症状的改善。总之，这些研究表明，10项耶鲁-布朗量表是一个可靠和有效的工具，用于评估强迫症症状的严重程度，它是适合作为一个结果的措施，在药物试验的强迫症。
The development design and reliability of the Yale-Brown Obsessive Compulsive Scale have been described elsewhere. We focused on the validity of the Yale-Brown Scale and its sensitivity to change. Convergent and discriminant validity were examined in baseline ratings from three cohorts of patients with obsessive-compulsive disorder (N = 81). The total Yale-Brown Scale score was significantly correlated with two of three independent measures of obsessive-compulsive disorder and weakly correlated with measures of depression and of anxiety in patients with obsessive-compulsive disorder with minimal secondary depressive symptoms. Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale-Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive-compulsive disorder symptoms. Together, these studies indicate that the 10-item Yale-Brown Scale is a reliable and valid instrument for assessing obsessive-compulsive disorder symptom severity and that it is suitable as an outcome measure in drug trials of obsessive-compulsive disorder.