Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
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DOI：
10.1111/ene.15254
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发表时间：
2022-05
影响因子：
5.1
通讯作者：
Mochizuki, Hideki
中科院分区：
文献类型：
--
作者：
Ikenaka, Kensuke;Maeda, Yasuhiro;Hotta, Yuji;Nagano, Seiichi;Yamada, Shinichiro;Ito, Daisuke;Torii, Ryota;Kakuda, Keita;Tatebe, Harutsugu;Atsuta, Naoki;Aguirre, Cesar;Kimura, Yasuyoshi;Baba, Kousuke;Tokuda, Takahiko;Katsuno, Masahisa;Kimura, Kazunori;Sobue, Gen;Mochizuki, Hideki
目的是研究血清不对称二甲基精氨酸 (ADMA) 水平与肌萎缩侧索硬化症 (ALS) 的进展和预后之间的关联，并将脑脊液 (CSF) 和血清 ADMA 水平与 ALS 的其他生物标志物进行比较。使用液相色谱串联质谱法测量散发性 ALS 患者 (n = 68)、疾病控制患者 (n = 54) 和健康对照 (n = 20) 的血清 ADMA 水平。分析了 ADMA 水平和其他标志物（一氧化氮和神经丝轻链水平）的相关性。自疾病发作以来 ALS 功能评定量表修订版 (ALSFRS-R) 评分的变化（ALSFRS-R 前斜率）用于评估疾病进展。使用 Cox 比例风险模型和 Kaplan-Meier 分析评估生存率。 ALS 患者的血清 ADMA 水平显着高于健康对照和疾病对照。血清 ADMA 水平与 CSF ADMA 水平相关（r = 0.591，p < 0.0001），并且与 ALSFRS-R 前斜率独立相关（r = 0.505，p < 0.0001）。血清 ADMA 水平较高的患者预后较差。 CSF ADMA 水平与 CSF 神经丝轻链水平显着相关（r = 0.456，p = 0.0002），但与一氧化氮水平无关（r = 0.194，p = 0.219）。血清ADMA水平是ALS疾病进展和预后的独立生物标志物，反映运动神经元变性程度。 Kaplan-Meier曲线显示血清ADMA水平较高的患者预后较差。
The aim was to investigate the association between serum asymmetric dimethylarginine (ADMA) levels and the progression and prognosis of amyotrophic lateral sclerosis (ALS), and to compare cerebrospinal fluid (CSF) and serum ADMA levels with other biomarkers of ALS. Serum ADMA levels of sporadic ALS patients (n = 68), disease control patients (n = 54) and healthy controls (n = 20) were measured using liquid chromatography tandem mass spectrometry. Correlations of the ADMA level and other markers (nitric oxide and neurofilament light chain levels) were analyzed. Changes in the ALS Functional Rating Scale Revised (ALSFRS‐R) score from the onset of disease (ALSFRS‐R pre‐slope) was used to assess disease progression. Survival was evaluated using the Cox proportional hazards model and Kaplan–Meier analysis. The serum ADMA level was substantially higher in patients with ALS than in healthy controls and disease controls. Serum ADMA level correlated with CSF ADMA level (r = 0.591, p < 0.0001) and was independently associated with the ALSFRS‐R pre‐slope (r = 0.505, p < 0.0001). Patients with higher serum ADMA levels had less favorable prognoses. CSF ADMA level significantly correlated with CSF neurofilament light chain level (r = 0.456, p = 0.0002) but not with nitric oxide level (r = 0.194, p = 0.219). Serum ADMA level is an independent biomarker of ALS disease progression and prognosis and reflects the degree of motor neuron degeneration. Kaplan‐Meier curve showed that the patients with higher serum ADMA levels had a worse prognosis.
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影响因子：
5.3
作者：
Menke RA;Gray E;Lu CH;Kuhle J;Talbot K;Malaspina A;Turner MR
通讯作者：
Turner MR
影响因子：
2.1
作者：
Kennedy, KJ;Simandan, TL;Dix, TA
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Dix, TA
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Tumani, H
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通讯作者：
Patani, Rickie
影响因子：
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作者：
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Mora, Gabriele