Bacterial Exotoxins and the Inflammasome.
Bacterial Exotoxins and the Inflammasome.
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DOI：
10.3389/fimmu.2015.00570
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发表时间：
2015
影响因子：
7.3
通讯作者：
Moayeri M
中科院分区：
文献类型：
--
作者：
Greaney AJ;Leppla SH;Moayeri M
炎性小体是细胞内的蛋白质复合物，在先天免疫感应中起重要作用。炎性小体的活化导致半胱天冬酶-1的活化以及促炎细胞因子白细胞介素（IL）-1β和IL-18的成熟和分泌。在某些骨髓细胞中，这种活化也可导致炎性细胞死亡（焦亡）。炎性体传感器蛋白已经进化为通过直接相互作用或通过检测由这些效应物引起的宿主细胞变化来检测一系列微生物配体和细菌外毒素。细菌外毒素通过不同的过程激活炎性小体，包括直接传感器裂解、通过质膜孔形成调节离子通量以及干扰各种宿主细胞功能。在这篇综述中，我们总结了一些细菌外毒素激活炎性小体的研究结果。
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have evolved to detect a range of microbial ligands and bacterial exotoxins either through direct interaction or by detection of host cell changes elicited by these effectors. Bacterial exotoxins activate the inflammasomes through diverse processes, including direct sensor cleavage, modulation of ion fluxes through plasma membrane pore formation, and perturbation of various host cell functions. In this review, we summarize the findings on some of the bacterial exotoxins that activate the inflammasomes.