Muscle creatine content in rats given repeated large doses of nicotinamide: effects of dietary methionine, choline, carnitine, and other supplements.
Muscle creatine content in rats given repeated large doses of nicotinamide: effects of dietary methionine, choline, carnitine, and other supplements.
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重复给予大剂量烟酰胺的大鼠的肌肉肌酸含量：膳食蛋氨酸、胆碱、肉碱和其他补充剂的影响。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
M. Swendseid
中科院分区：
文献类型：
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作者：
S. Sun;R. Mckee;J. Fisler;M. Swendseid
在三项实验中，给喂食 12% 酪蛋白饮食且不添加胆碱的大鼠长期注射药理学剂量的烟酰胺 (NAM)，持续 18 至 28 天。除了脂肪肝和体重增加较少之外，NAM 治疗组的心脏和骨骼肌肌酸含量也低于注射盐水的对照大鼠。膳食补充剂蛋氨酸可以防止这些改变，而胆碱，根据补充水平，也有一些类似的效果。补充肉碱、组氨酸或叶酸加维生素 B-12 并不能证明一致的反应。
Rats fed a 12% casein diet without added choline were chronically injected with pharmacologic doses of nicotinamide (NAM) for 18 to 28 d in three experiments. In addition to fatty livers and lower weight gains, the creatine content of heart and skeletal muscle was lower in NAM-treated than in control saline-injected rats. Dietary supplements of methionine prevented these alterations, and choline, depending on the level of supplementation, also had some similar effects. No consistent responses could be demonstrated by supplements of carnitine, histidine or folic acid plus vitamin B-12.