Counteraction of antibiotic production and degradation stabilizes microbial communities.
Counteraction of antibiotic production and degradation stabilizes microbial communities.
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DOI：
10.1038/nature14485
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发表时间：
2015-05-28
期刊：
影响因子：
64.8
通讯作者：
Kishony R
中科院分区：
文献类型：
--
作者：
Kelsic ED;Zhao J;Vetsigian K;Kishony R
理论生态学的一个主要挑战是理解自然微生物群落如何支持物种多样性，特别是抗生素生产，敏感和耐药物种如何共存。虽然循环的“石头剪刀布”相互作用可以稳定空间环境中的社区，但在非结构化环境中共存仍然是一个谜。在这里，使用模拟和分析模型，我们表明抗生素生产和降解的相反作用即使在混合良好的环境中也能共存。共存依赖于3向相互作用，其中抗生素降解物质减弱了两个其他物质之间的抑制性相互作用。这些3向相互作用使得能够共存，其对于固有物种生长速率的实质性差异和停止产生或降解抗生素的“欺骗”物种的入侵是稳健的。稳定性至少需要两种抗生素，更多的抗生素可以实现更复杂的社区和多样化的动力学行为，从稳定的不动点到极限环和混沌。总之，这些结果显示了多物种抗生素相互作用如何在空间和混合微生物群落中产生生态稳定性，提出了工程合成生态系统的策略，并强调了毒素产生和降解对微生物生物多样性的重要性。
A major challenge in theoretical ecology is understanding how natural microbial communities support species diversity, and in particular how antibiotic producing, sensitive and resistant species coexist. While cyclic “rock-paper-scissors” interactions can stabilize communities in spatial environments, coexistence in unstructured environments remains an enigma. Here, using simulations and analytical models, we show that the opposing actions of antibiotic production and degradation enable coexistence even in well-mixed environments. Coexistence depends on 3-way interactions where an antibiotic degrading species attenuates the inhibitory interactions between two other species. These 3-way interactions enable coexistence that is robust to substantial differences in inherent species growth rates and to invasion by “cheating” species that cease producing or degrading antibiotics. At least two antibiotics are required for stability, with greater numbers of antibiotics enabling more complex communities and diverse dynamical behaviors ranging from stable fixed-points to limit cycles and chaos. Together, these results show how multi-species antibiotic interactions can generate ecological stability in both spatial and mixed microbial communities, suggesting strategies for engineering synthetic ecosystems and highlighting the importance of toxin production and degradation for microbial biodiversity.