Processing of odor mixtures in the Drosophila antennal lobe reveals both global inhibition and glomerulus-specific interactions
Processing of odor mixtures in the Drosophila antennal lobe reveals both global inhibition and glomerulus-specific interactions
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DOI：
10.1523/jneurosci.3099-07.2007
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发表时间：
2007-10-31
影响因子：
5.3
通讯作者：
Galizia, C. Giovanni
中科院分区：
文献类型：
--
作者：
Silbering, Ana F.;Galizia, C. Giovanni
为了了解气味信息是如何在果蝇触角叶（AL）的代表和处理，我们光学记录肾小球钙反应的单一气味和气味混合物的嗅觉感觉神经元（OSNs）和投射神经元（PNs）。气味混合物提供了一个很好的工具来分析气味处理，因为实验结果可以测试对明确的预测。在OSN水平上，气味混合物的表征在大多数情况下可以从组分的响应模式中预测。PN反应的混合物，但是，肾小球间抑制的证据。应用印防己毒素（PTX），GABA（A）样受体的拮抗剂，增强气味反应，改变其时间进程，并消除PN水平的混合物抑制。我们的研究结果可以最好地解释通过假设存在至少两个本地网络在飞AL：肾小球特定的网络，其中包括兴奋性和抑制性连接和PTX敏感的抑制性全球网络，其作用于所有肾小球与全球AL输入成比例的强度。
To understand how odor information is represented and processed in the antennal lobe (AL) of Drosophila melanogaster, we have optically recorded glomerular calcium responses to single odors and odor mixtures from olfactory sensory neurons (OSNs) and projection neurons (PNs). Odor mixtures offer a good tool to analyze odor processing because experimental results can be tested against clear predictions. At the level of the OSNs, the representation of odor mixtures could be predicted from the response patterns of the components in most cases. PN responses to mixtures, however, provide evidences of interglomerular inhibition. Application of picrotoxin (PTX), an antagonist of GABA(A)-like receptors, enhanced odor responses, modified their temporal course, and eliminated mixture suppression at the PN level. Our results can be best explained by postulating the existence of at least two local networks in the fly AL: a glomerulus specific network, which includes excitatory and inhibitory connections and a PTX sensitive inhibitory global network that acts on all glomeruli with proportional strength to the global AL input.