SIMILARITIES BETWEEN TRUNK AND SPATZLE, PUTATIVE EXTRACELLULAR LIGANDS SPECIFYING BODY PATTERN IN DROSOPHILA
SIMILARITIES BETWEEN TRUNK AND SPATZLE, PUTATIVE EXTRACELLULAR LIGANDS SPECIFYING BODY PATTERN IN DROSOPHILA
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DOI：
10.1101/gad.9.20.2539
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发表时间：
1995-10-15
影响因子：
10.5
通讯作者：
STRUHL, G
中科院分区：
文献类型：
--
作者：
CASANOVA, J;FURRIOLS, M;STRUHL, G
果蝇的基本身体平面是由沿前后轴和背腹轴组织图案的四个决定系统决定的。其中两个系统（前系统和后系统）依赖于局部mrna。相反，其他两种（腹侧和末端）需要局部生成的细胞外配体，分别由跨膜受体Toll和躯干（tor）转导。Toll受体的配体被认为是spatzle (spz)，一种由蛋白水解裂解激活的分泌蛋白。在这里，我们报告（trk），一个基因的活性所需的受体，编码的蛋白质在几个方面类似于spz。特别是，该序列表明，trk是一种分泌蛋白，它含有一个蛋白水解裂解的内部位点。此外，trk的羧基末端结构域具有与spz相似的半胱氨酸排列。我们提出trk编码参与指定终端体模式的细胞外配体，并建议通过与spz的类比，裂解形式的trk构成受体的配体。
The basic body plan of Drosophila is specified by four determinant systems that organize pattern along the anteroposterior and dorsoventral axes. Two of these systems (anterior and posterior) depend on localized mRNAs. In contrast, the other two (ventral and terminal) require locally generated extracellular ligands that are transduced, respectively, by the transmembrane receptors Toll and torso (tor). The ligand for the Toll receptor is thought to be spatzle (spz), a secreted protein that is activated by proteolytic cleavage. Here we report that (trk), a gene required for activity of the tor receptor, encodes a protein that resembles spz in several respects. In particular, the sequence suggests that trk is a secreted protein and that it contains an internal site for proteolytic cleavage. Furthermore, the carboxy-terminal domain of trk has a similar arrangement of cysteines to that of spz. We propose that trk encodes a extracellular ligand involved in specifying terminal body pattern and suggest by analogy with spz that a cleaved form of trk constitutes the ligand for the tor receptor.