PharmGED: Pharmacogenetic effect database
PharmGED: Pharmacogenetic effect database
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DOI：
10.1093/nar/gkl853
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发表时间：
2007-01-01
影响因子：
14.9
通讯作者：
Chen, Y. Z.
中科院分区：
文献类型：
--
作者：
Zheng, C. J.;Han, L. Y.;Chen, Y. Z.
遗传药理学效应的预测和阐明对于促进个体化药物的开发是重要的。需要了解多态性诱导的和其他类型的药物反应变异，以促进此类研究。虽然已经出现了药物遗传学知识、多态性和毒理基因组学信息数据库，但一些相关数据在单独的网页中提供，并引用了文献中相对较长的描述。为了便于对相关信息进行简单快速的评估，开发在同一网页中提供与药物遗传学效应相关的所有信息并进行简要描述的数据库是有帮助的。我们开发了一个数据库，药物遗传学效应数据库（PharmGED），提供序列，功能，多态性，影响药物和药物遗传学效应。PharmGED可以在http://bidd.cz3.nus.edu.sg/phg/free上访问，收费用于学术用途。它目前包含1825个条目，涵盖108种疾病，266种不同的蛋白质，693种多态性，414种药物/配体，引用了856篇参考文献。
Prediction and elucidation of pharmacogenetic effects is important for facilitating the development of personalized medicines. Knowledge of polymorphism-induced and other types of drug-response variations is needed for facilitating such studies. Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in separate web-pages and in terms of relatively long descriptions quoted from literatures. To facilitate easy and quick assessment of the relevant information, it is helpful to develop databases that provide all of the information related to a pharmacogenetic effect in the same web-page and in brief descriptions. We developed a database, Pharmacogenetic Effect Database (PharmGED), for providing sequence, function, polymorphism, affected drugs and pharmacogenetic effects. PharmGED can be accessed at http://bidd.cz3.nus.edu.sg/phg/free of charge for academic use. It currently contains 1825 entries covering 108 disease conditions, 266 distinct proteins, 693 polymorphisms, 414 drugs/ligands cited from 856 references.