Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life.
Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life.
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DOI：
10.1097/hjh.0b013e3283642f6c
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发表时间：
2013-11
影响因子：
4.9
通讯作者：
Garovic VD
中科院分区：
文献类型：
--
作者：
Brown CM;Turner ST;Bailey KR;Mosley TH Jr;Kardia SL;Wiste HJ;Kullo IJ;Garovic VD
We assessed if hypertension in pregnancy is associated with elevated CRP levels in later life, possibly reflecting an increased risk of CVD. Elevated C-reactive protein (CRP) levels have been associated with hypertension in pregnancy and with cardiovascular disease (CVD). We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Subjects were categorized as nulliparous women (n=219), women with a history of normotensive pregnancies (n=1839), or women with a history of a hypertensive pregnancy (n=405). Using multiple linear regression models we compared mean CRP levels among the groups after adjusting for age, race, education, smoking, hypertension, personal history of CHD or stroke, diabetes, dyslipidemia, statins, hormone replacement therapy, and family history of CHD or stroke. As CRP levels may be influenced by body mass index (BMI), the model was fit both with and without adjusting for BMI. There was no significant difference in CRP levels between nulliparous women and those with a history of normotensive pregnancies, either with (p=0.82) or without (p=0.46) adjusting for BMI. In contrast, women with hypertensive pregnancies, compared to those with normotensive pregnancies, had higher CRP levels, both with (p=0.009) and without (p<0.001) adjusting for BMI. A history of hypertension in pregnancy is associated with elevated CRP levels later in life, independent of traditional CVD risk factors and BMI. An elevated CRP may reflect an inflammatory state in women with a history of hypertensive pregnancy disorders who are at increased risk for CVD.
