Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study.
Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study.
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DOI：
10.3389/fcvm.2023.1172828
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发表时间：
2023
影响因子：
3.6
通讯作者：
Meyer, Michelle L.
中科院分区：
文献类型：
--
作者：
Bonner, Alison N.;Jayawickreme, Shantal;Malek, Angela M.;Vladutiu, Catherine J.;Oliver-Williams, Clare;Cortes, Yamnia I.;Tanaka, Hirofumi;Meyer, Michelle L.
关键词：
虽然研究表明胎次与心血管疾病（CVD）之间存在j型关联，但与动脉僵硬的关联尚不完全清楚。我们研究了胎次与颈-股脉波速度（cfPWV）之间的关系，cfPWV是衡量中心动脉硬度的一种指标。我们对参加社区动脉粥样硬化风险研究访问5（2011-2013）的1220名女性（平均年龄73.7岁）进行了纵向分析。在第2次访问（1990-1992）中，妇女自我报告胎次（以前活产的数量），我们将其分类为：0（从未怀孕或怀孕但没有活产）；1 - 2 (referent);3 - 4;5个以上的活产。技术人员在第5次访问（2011-2013年）和第6或7次访问（2016-2019年）时测量了cfPWV。多变量线性回归模拟了第5次就诊的平价cfPWV和第5次至6/7次就诊的cfPWV变化之间的关联，并根据人口统计学和潜在的混杂因素进行了调整。参与者报告0（7.7%）、1-2（38.7%）、3-4（40.0%）或5+(13.6%)胎活产。在调整分析中，5个以上活产的妇女比1-2个活产的妇女有更高的5 cfPWV （β=50.6 cm/s， 95%可信区间：3.6,97.7 cm/s）。其他胎次组与第5次cfPWV或cfPWV变化无统计学意义的关联。在以后的生活中，活产5个以上的妇女比活产1-2个的妇女动脉僵硬度更高，但cfPWV的变化并没有因胎次而不同，这表明，活产5个以上的妇女在晚年的动脉僵硬度更高，因此应该针对她们进行心血管疾病的早期一级预防。
Although studies have demonstrated a J-shaped association between parity and cardiovascular disease (CVD), the association with arterial stiffness is not fully understood. We examined the association between parity and carotid-femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness. We conducted a longitudinal analysis of 1220 women (mean age 73.7 years) who attended the Atherosclerosis Risk in Communities Study visit 5 (2011-2013). At visit 2 (1990-1992), women self-reported parity (number of prior live births), which we categorized as: 0 (never pregnant or pregnant with no live births); 1-2 (referent); 3-4; and 5+ live births. Technicians measured cfPWV at visit 5 (2011-2013) and visit 6 or 7 (2016-2019). Multivariable linear regression modeled the associations of parity with visit 5 cfPWV and cfPWV change between visit 5 and 6/7 adjusted for demographics and potential confounding factors. Participants reported 0 (7.7%), 1-2 (38.7%), 3-4 (40.0%), or 5+ (13.6%) prior live births. In adjusted analyses, women with 5+ live births had a higher visit 5 cfPWV (β=50.6 cm/s, 95% confidence interval: 3.6, 97.7 cm/s) than those with 1-2 live births. No statistically significant associations were observed for other parity groups with visit 5 cfPWV or with cfPWV change. In later life, women with 5+ live births had higher arterial stiffness than those with 1-2 live births, but cfPWV change did not differ by parity, suggesting women with 5+ live births should be targeted for early primary prevention of CVD given their higher arterial stiffness at later-life.
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影响因子：
20.1
作者：
Garcia M;Mulvagh SL;Merz CN;Buring JE;Manson JE
通讯作者：
Manson JE
影响因子：
5
作者：
Must, A;Phillips, SM;Rand, WM
通讯作者：
Rand, WM
影响因子：
8.3
作者：
Unger, Thomas;Borghi, Claudio;Schutte, Aletta E.
通讯作者：
Schutte, Aletta E.
影响因子：
2.8
作者：
Cortez-Cooper, MY;Supak, JA;Tanaka, H
通讯作者：
Tanaka, H
影响因子：
3.2
作者：
Meyer, Michelle L.;Tanaka, Hirofumi;Heiss, Gerardo
通讯作者：
Heiss, Gerardo