SARS-CoV-2 Survival on Surfaces and the Effect of UV-C Light.
SARS-CoV-2 Survival on Surfaces and the Effect of UV-C Light.
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DOI：
10.3390/v13030408
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发表时间：
2021-03-05
期刊：
影响因子：
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通讯作者：
Francisci D
中科院分区：
文献类型：
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作者：
Gidari A;Sabbatini S;Bastianelli S;Pierucci S;Busti C;Bartolini D;Stabile AM;Monari C;Galli F;Rende M;Cruciani G;Francisci D
本研究的目的是建立持久性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在无生命的表面，如塑料，不锈钢，玻璃在UV-C照射，这是一种常用的物理手段消毒程序。评估了UV-C照射后的病毒灭活率、病毒半衰期和滴度降低百分比。在塑料和玻璃上保持电阻率直到120小时，在不锈钢上保持电阻率直到72小时。在塑料、不锈钢和玻璃上的病毒半衰期分别为5.3、4.4和4.2 h。在所有情况下，滴干后滴度衰减>99%。UV-C辐射有效地降低了病毒滴度（99.99%），剂量范围为10.25至23.71 mJ/cm 2。塑料和不锈钢需要更高的剂量才能实现目标减少。玻璃上的SARS-CoV-2在较低剂量下获得完全灭活。SARS-CoV-2在无生命的表面上可以长期存活。值得推荐有效的消毒方案作为预防病毒传播的措施。UV-C可以为不同的材料和表面提供快速、高效和可持续的消毒程序。辐射的剂量和模式是实施时要考虑的重要参数，是抗击SARS-CoV-2大流行的重要手段。
The aim of this study was to establish the persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on inanimate surfaces such as plastic, stainless steel, and glass during UV-C irradiation which is a physical means commonly utilized in sanitization procedures. The viral inactivation rate, virus half-life, and percentage of titer reduction after UV-C irradiation were assessed. Infectivity was maintained on plastic and glass until 120 h and on stainless steel until 72 h. The virus half-life was 5.3, 4.4, and 4.2 h on plastic, stainless steel, and glass, respectively. In all cases, titer decay was >99% after drop drying. UV-C irradiation efficiently reduced virus titer (99.99%), with doses ranging from 10.25 to 23.71 mJ/cm2. Plastic and stainless steel needed higher doses to achieve target reduction. The total inactivation of SARS-CoV-2 on glass was obtained with the lower dose applied. SARS-CoV-2 survival can be long lasting on inanimate surfaces. It is worth recommending efficient disinfection protocols as a measure of prevention of viral spread. UV-C can provide rapid, efficient and sustainable sanitization procedures of different materials and surfaces. The dosages and mode of irradiation are important parameters to consider in their implementation as an important means to fight the SARS-CoV-2 pandemic.