Challenges for Molecular Neuroimaging with MRI.
Challenges for Molecular Neuroimaging with MRI.
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DOI：
10.1002/ima.20221
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发表时间：
2010-03
影响因子：
3.3
通讯作者：
Jasanoff, Alan
中科院分区：
文献类型：
--
作者：
Lelyveld, Victor S.;Atanasijevic, Tatjana;Jasanoff, Alan
基于磁共振（MRI）的分子成像方法开始对神经科学产生影响。越来越多的分子成像剂在体外合成和测试，但到目前为止，在活动物的大脑中，几乎没有得到验证。在这里，我们讨论了与扩大成功分子神经影像学方法的曲目相关的关键挑战。在中枢神经系统中，传递药物超越血脑屏障（BBB）的困难是分子成像的特殊障碍。我们审查了用于反式BBB传递的建立和新兴技术，包括颅内输注，BBB破坏和与转运蛋白相关的方法。提高基于MRI的分子剂的敏感性是第二个主要挑战。更好的敏感性反过来会减少交付的要求并减轻潜在的副作用。我们讨论了最新的努力，以提高常规纵向松弛时间（T1）和横向松弛时间（T2）MRI对比剂的松弛性，以及涉及放大分子信号或减少内源性背景影响的策略。随着成像方法和大脑递送方法的持续改进，用于分子级神经科学研究的基于MRI的技术将越来越多。
Magnetic resonance (MRI)-based molecular imaging methods are beginning to have impact in neuroscience. A growing number of molecular imaging agents have been synthesized and tested in vitro, but so far relatively few have been validated in the brains of live animals. Here, we discuss key challenges associated with expanding the repertoire of successful molecular neuroimaging approaches. The difficulty of delivering agents past the blood-brain barrier (BBB) is a particular obstacle to molecular imaging in the central nervous system. We review established and emerging techniques for trans-BBB delivery, including intracranial infusion, BBB disruption, and transporter-related methods. Improving the sensitivity with which MRI-based molecular agents can be detected is a second major challenge. Better sensitivity would in turn reduce the requirements for delivery and alleviate potential side effects. We discuss recent efforts to enhance relaxivity of conventional longitudinal relaxation time (T1) and transverse relaxation time (T2) MRI contrast agents, as well as strategies that involve amplifying molecular signals or reducing endogenous background influences. With ongoing refinement of imaging approaches and brain delivery methods, MRI-based techniques for molecular-level neuroscientific investigation will fall increasingly within reach.
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影响因子：
18.3
作者：
De Leon-Rodriguez, Luis M.;Lubag, Angelo Josue M.;Malloy, Craig R.;Martinez, Gary V.;Gillies, Robert J.;Sherry, A. Dean
通讯作者：
Sherry, A. Dean
影响因子：
4.6
作者：
Cohen, SM;Xu, JD;Aime, S
通讯作者：
Aime, S
影响因子：
3.3
作者：
Cunningham, CH;Arai, T;Conolly, SM
通讯作者：
Conolly, SM
影响因子：
--
作者：
Caravan, Peter;Farrar, Christian T.;Frullano, Luca;Uppal, Ritika
通讯作者：
Uppal, Ritika
DOI：
10.1001/archneurpsyc.1956.02330290001001
发表时间：
1956-01-01
影响因子：
--
作者：
BAKAY, L;HUETER, TF;SOSA, D
通讯作者：
SOSA, D