Specific amino acids inhibit food intake via the area postrema or vagal afferents
Specific amino acids inhibit food intake via the area postrema or vagal afferents
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DOI：
10.1113/jphysiol.2013.258947
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发表时间：
2013-11-15
影响因子：
5.5
通讯作者：
Verrey, Francois
中科院分区：
文献类型：
--
作者：
Jordi, Josua;Herzog, Brigitte;Verrey, Francois
为了维持营养平衡，中枢神经系统整合促进或抑制进食的信号。重要氨基酸的供应是通过根据膳食蛋白质含量调整食物摄入量来调节的。我们假设这种效应是基于对单个氨基酸的感知作为控制食物摄入的信号。在这里，我们表明，食物摄入量是最有效地减少口服L-精氨酸（Arg），L-赖氨酸（Lys）和L-谷氨酸（Glu）相比，所有其他17种蛋白质氨基酸在大鼠。这三种氨基酸诱导的最后区和孤束核的神经元活动。手术损毁最后区可阻断对精氨酸和谷氨酸的厌食反应，而损毁迷走神经传入可阻断对赖氨酸的反应。这三种氨基酸也通过差异性改变胃分泌和/或排空引起胃扩张。重要的是，这些外周机械迷走神经刺激与氨基酸对食物摄入的影响无关。因此，精氨酸，赖氨酸和谷氨酸对食品加工和摄入量有选择性的影响，这表明它们作为直接的感官输入，以评估体内膳食蛋白质含量和质量。总的来说，这项研究揭示了控制食物摄入和胃肠道功能的新的氨基酸特异性机制。
To maintain nutrient homeostasis the central nervous system integrates signals that promote or inhibit eating. The supply of vital amino acids is tuned by adjusting food intake according to its dietary protein content. We hypothesized that this effect is based on the sensing of individual amino acids as a signal to control food intake. Here, we show that food intake was most potently reduced by oral l-arginine (Arg), l-lysine (Lys) and l-glutamic acid (Glu) compared to all other 17 proteogenic amino acids in rats. These three amino acids induced neuronal activity in the area postrema and the nucleus of the solitary tract. Surgical lesion of the area postrema abolished the anorectic response to Arg and Glu, whereas vagal afferent lesion prevented the response to Lys. These three amino acids also provoked gastric distension by differentially altering gastric secretion and/or emptying. Importantly, these peripheral mechanical vagal stimuli were dissociated from the amino acids' effect on food intake. Thus, Arg, Lys and Glu had a selective impact on food processing and intake suggesting them as direct sensory input to assess dietary protein content and quality in vivo. Overall, this study reveals novel amino acid-specific mechanisms for the control of food intake and of gastrointestinal function.