Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China
Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China
复制标题
新疆伊犁地区人群COMT和XPD多态性与食管鳞癌患病风险
DOI：
10.3109/1354750x.2010.522732
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发表时间：
2011-02-01
期刊：
影响因子：
2.6
通讯作者：
Lu, Xiao-mei
中科院分区：
文献类型：
--
作者：
Huang, Cong-Gai;Iv, Guo-dong;Lu, Xiao-mei
目的：目的：探讨新疆伊犁地区人群中COMT（Rs 4680）和XPD（Rs 13181）基因多态性与食管鳞状细胞癌（ESCC）的关系。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法进行基因分型。结果：COMT与A等位基因的出现频率相关（Rs 4680; OR1.30，95%CI1.00 -1.68），ESCC的危险性增加。COMT 158（瓦尔/Met或Met/Met）和XPD 751（Lys/Gln或Gln/Gln）基因型联合携带者ESCC风险增加。
Objective: To investigate polymorphisms of COMT (Rs4680) and XPD (Rs13181) and risk of esophageal squamous cell carcinoma (ESCC) in a population from Yili Prefecture, Xinjiang, China.Methods: A hospital-based case-control study was designed. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and 95% confidence intervals (CI) were analysed using unconditional logistic regression.Results: An increased risk of ESCC was discovered with COMT in relation to the frequency of the presence of the A allele (Rs4680; OR 1.30, 95% CI 1.00-1.68). An individual with combined COMT 158 (Val/Met or Met/Met) and XPD 751 (Lys/Gln or Gln/Gln) genotype had an increased ESCC risk.Conclusions: Polymorphic variation in COMT Val158Met and XPD Lys751Gln may be important for ESCC susceptibility.