Biological measurement beyond the quantum limit
Biological measurement beyond the quantum limit
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DOI：
10.1038/nphoton.2012.346
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发表时间：
2013-03-01
期刊：
影响因子：
35
通讯作者：
Bowen, Warwick P.
中科院分区：
文献类型：
--
作者：
Taylor, Michael A.;Janousek, Jiri;Bowen, Warwick P.
动态生物学测量需要低光照水平，以避免损坏标本。由于对光功率的这种限制，量子噪声从根本上限制了测量灵敏度。只有通过使用量子关联来提取每个光子更多的信息，才能超过这个极限。在这里，我们实验证明，量子散粒噪声限制可以克服测量的生活系统。振幅噪声压缩75%以下的真空水平的量子相关光被用来进行微观流变学实验中的酿酒酵母细胞。当天然存在的脂质颗粒通过细胞质扩散时，可以真实的时间跟踪它们，并且量子噪声极限超过42%。所使用的基于激光的微粒跟踪技术与非经典光兼容，并且不受低频噪声的影响，这为实现生物学中广泛的量子增强测量开辟了道路。
Dynamic biological measurements require low light levels to avoid damaging the specimen. With this constraint on optical power, quantum noise fundamentally limits the measurement sensitivity. This limit can only be surpassed by extracting more information per photon by using quantum correlations. Here, we experimentally demonstrate that the quantum shot noise limit can be overcome for measurements of living systems. Quantum-correlated light with amplitude noise squeezed 75% below the vacuum level is used to perform microrheology experiments within Saccharomyces cerevisiae yeast cells. Naturally occurring lipid granules are tracked in real time as they diffuse through the cytoplasm, and the quantum noise limit is surpassed by 42%. The laser-based microparticle tracking technique used is compatible with non-classical light and is immune to low-frequency noise, leading the way to achieving a broad range of quantum-enhanced measurements in biology.