Oxidative stress in Dahl salt-sensitive hypertension
Oxidative stress in Dahl salt-sensitive hypertension
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DOI：
10.1161/01.hyp.0000070028.99408.e8
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发表时间：
2003-06-01
期刊：
影响因子：
8.3
通讯作者：
Manning, RD
中科院分区：
文献类型：
--
作者：
Meng, SM;Cason, GW;Manning, RD
在达尔盐敏感大鼠中研究了氧化应激在动脉压、肾血流动力学和肾损伤的长期调节中的作用。对28只Dahl S/Rapp品系大鼠（配备留置动脉和静脉导管）进行3周静脉输注低Na（0.9 mmol/d）或高Na（20.6 mmol/d）或超氧化物歧化酶模拟物4-羟基-2，2，6，6-四甲基哌啶-1-氧基（Tempol），输注时间为125 mumol.kg（-1）.h（-1），外加低Na或高Na。21天后，高钠组的平均动脉压为140+/-3 mmHg，高钠组为118+/-1 mmHg（P
The role of oxidative stress in the long-term regulation of arterial pressure, renal hemodynamics, and renal damage was studied in Dahl salt-sensitive rats. Twenty-eight Dahl S/Rapp strain rats, equipped with indwelling arterial and venous catheters, were subjected to a 3-week intravenous infusion of either low Na (0.9 mmol/d) or high Na (20.6 mmol/d) or the superoxide dismutase mimetic, 4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol), at 125 mumol.kg(-1).h(-1) plus low Na or high Na. After 21 days, mean arterial pressure was 140+/-3 mm Hg in the high-Na group, 118+/-1 mmHg (P