SEX AND SPECIES-DIFFERENCES IN THE VASOPRESSIN INNERVATION OF SEXUALLY NAIVE AND PARENTAL PRAIRIE VOLES, MICROTUS-OCHROGASTER AND MEADOW VOLES, MICROTUS-PENNSYLVANICUS
SEX AND SPECIES-DIFFERENCES IN THE VASOPRESSIN INNERVATION OF SEXUALLY NAIVE AND PARENTAL PRAIRIE VOLES, MICROTUS-OCHROGASTER AND MEADOW VOLES, MICROTUS-PENNSYLVANICUS
复制标题
DOI：
10.1111/j.1365-2826.1993.tb00480.x
复制
发表时间：
1993-06-01
影响因子：
3.2
通讯作者：
DEVRIES, GJ
中科院分区：
文献类型：
--
作者：
BAMSHAD, M;NOVAK, MA;DEVRIES, GJ
为了研究与生殖功能相关的中枢系统是否在雄性和雌性成为父母后表现出不同的变化，比较了两种田鼠的中枢血管加压素（AVP）神经支配：草原田鼠，其中雄性和雌性提供父母照顾，草甸田鼠，其中只有雌性提供父母照顾。对于这两个物种，AVP-免疫反应（AVP-IR）纤维在外侧隔，外侧缰核，内侧视前区和室旁核的丘脑的密度进行了比较，在男性和女性的性经验不足，或已成为父母牺牲前6天。外侧隔和外侧缰核的投射可能来自终纹床核和杏仁内侧核，而其他两个区域的投射可能来自视交叉上核。性幼稚和父母的动物之间的差异，发现只有在假定的预测的床核的终纹和内侧杏仁核。在这两个物种中，AVP-IR纤维密度在外侧缰核和外侧隔的男性比女性更大，无论父母的状态。在草原田鼠中，侧隔和外侧缰核的AVP免疫反应纤维密度在双亲雄性中减少，而在雌性中没有发现差异。亲代草甸田鼠外侧隔区AVP免疫阳性纤维密度无明显变化，外侧缰核区AVP免疫阳性纤维密度增加。AVP-IR纤维密度在父母草原田鼠男性和草甸田鼠男性没有这样的减少可能与他们的父母照顾的贡献的差异。
To study whether central systems that are implicated in functions associated with reproduction show different changes in males and females that become parental, the central vasopressin (AVP) innervation was compared in two species of voles: prairie voles, in which males and females provide parental care, and meadow voles, in which only females provide parental care. For both species, the densities of AVP-immunoreactive (AVP-ir) fibers in the lateral septum, lateral habenular nucleus, medial preoptic area and paraventricular nucleus of the thalamus were compared in males and females that were sexually inexperienced or had become parents 6 days before sacrifice. The lateral septum and lateral habenular nucleus presumably receive their projections from the bed nucleus of the stria terminalis and medial amygdaloid nucleus, while the other two areas presumably receive their projections from the suprachiasmatic nucleus. Differences between sexually naive and parental animals were found only in the presumed projections of the bed nucleus of the stria terminalis and medial amygdaloid nucleus. In both species, AVP-ir fiber densities in the lateral habenular nucleus and the lateral septum were much greater in males than in females regardless of parental state. In prairie voles, AVP-ir fiber density in the lateral septum and lateral habenular nucleus was reduced in parental males, while no differences were found in females. In parental meadow voles, the AVP-ir fiber density in the lateral septum did not show changes, while the fiber density in the lateral habenular nucleus was increased. The reduction in AVP-ir fiber density in parental prairie vole males and the absence of such a reduction in meadow vole males may be related to differences in their contribution to parental care.