HISTOLOGIC BASIS OF OPTIC DISK PALLOR IN EXPERIMENTAL OPTIC ATROPHY
HISTOLOGIC BASIS OF OPTIC DISK PALLOR IN EXPERIMENTAL OPTIC ATROPHY
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DOI：
10.1016/0002-9394(77)90138-6
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发表时间：
1977-01-01
影响因子：
4.2
通讯作者：
ANDERSON, DR
中科院分区：
文献类型：
--
作者：
QUIGLEY, HA;ANDERSON, DR
本文报道了松鼠猴（Saimiri sciureus）眶尖视神经切断后视神经变性的临床和显微镜表现。眼底镜下视盘苍白的发展正好与神经纤维束的损失和剩余的盘星形胶质细胞重排成致密的平行层横跨神经头。未观察到星形胶质细胞有丝分裂，星形胶质细胞的估计体积仅比正常值略有增加。萎缩盘内的星形胶质细胞中，许多毛细血管管腔通畅，内皮细胞超微结构正常。苍白的视盘似乎是由于减少光传输到萎缩的神经头的细胞结构，而不是从毛细血管的情况下，或从广泛的星形胶质细胞增殖。
The clinical and microscopic appearances of the optic nerve head were studied in squirrel monkeys [Saimiri sciureus] with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaining disk astrocytes into dense parallel layers across the nerve head. No astrocytic mitoses were observed and the estimated volume of astrocytes increased only slightly from normal. Among the astrocytes in atrophic disks, many capillaries had patent lumens and ultrastructurally normal endothelial cells. Pallor of the optic disk seemed to result from a decrease in the transmission of light into the cytoarchitecture of the atrophic nerve head, not from the absence of capillaries or from extensive astrocytic proliferation.