Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma.
Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma.
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DOI：
10.1016/j.oooo.2013.10.012
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Valentino J
中科院分区：
文献类型：
--
作者：
Swanson HI;Choi EY;Helton WB;Gairola CG;Valentino J
芹菜素和山奈酚是具有化学预防活性的植物类黄酮。本研究旨在研究芹菜素和山奈酚对培养的咽部细胞（FaDu细胞系）、口腔癌细胞（PCI-13细胞系）、转移性淋巴结细胞（PCI-15B细胞系）和外植的FaDu细胞活力的影响。测定芹菜素和山奈酚处理后FaDu、PCI-13和PCI-15B细胞的体外活力。用芹菜素或山奈酚灌胃，观察FaDu外植体在胸腺小鼠体内的肿瘤生长情况。虽然芹菜素和山奈酚处理降低了细胞的体外活力，但观察到细胞类型依赖性的反应性差异。体内芹菜素处理显著增加了FaDu外植体的肿瘤大小。山奈酚得到的结果相似。在本研究条件下，未观察到芹菜素和山奈酚对体外肿瘤外植体FaDu细胞活力的降低。
Apigenin and kaempferol are plant flavonoids with reported chemopreventive activities. This study aimed to determine the effect of apigenin and kaempferol on cell viability in cultured cells derived from the pharynx (FaDu cell line), an oral cavity carcinoma (PCI-13 cell line), and a metastatic lymph node (PCI-15B cell line) and in explanted FaDu cells. The in vitro viability of FaDu, PCI-13, and PCI-15B cells treated with apigenin and kaempferol was determined. Tumor growth of FaDu explants was evaluated in athymic mice that were gavaged with either apigenin or kaempferol. Although apigenin and kaempferol treatment decreased viability of cells in vitro, cell-type-dependent differences in responsiveness were observed. In vivo apigenin treatment significantly increased the tumor size of FaDu explants. Results obtained using kaempferol were similar. The in vitro decrease in FaDu cell viability by apigenin and kaempferol was not observed in in vivo tumor explants using the conditions described in this study.
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影响因子：
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作者：
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