Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women.
Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women.
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DOI：
10.1016/j.urology.2009.06.078
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发表时间：
2009-11
期刊：
影响因子：
2.1
通讯作者：
Urologic Pelvic Pain Collaborative Research Network
中科院分区：
文献类型：
--
作者：
Clemens JQ;Calhoun EA;Litwin MS;McNaughton-Collins M;Kusek JW;Crowley EM;Landis JR;Urologic Pelvic Pain Collaborative Research Network
迄今为止，单独的条件特定的工具已被用来评估男性和女性泌尿系统疼痛的症状严重程度。在男性和女性中使用的单一工具将有助于评估涉及两种性别的临床试验和队列研究中的治疗反应。我们通过修改NIH慢性前列腺炎症状指数并添加问题，开发了泌尿生殖道疼痛指数（GUPI）。为了评估判别效度、同时效度和可靠性，我们在一个大型管理式护理人群中对1,653名男性和1,403名女性进行了GUPI。为了评估反应性，我们对47名完成NIH赞助的盆底物理治疗试验的男性和女性进行了GUPI。GUPI区分了患有慢性前列腺炎或间质性膀胱炎的男性、患有其他症状性疾病（排尿困难、尿频、慢性膀胱炎）的男性和没有这些诊断的男性（p<0.05）。它还区分了患有间质性膀胱炎的女性，患有失禁的女性和没有这些诊断的女性（p<0.05）。GUPI在子量表领域内表现出良好的内部一致性，GUPI评分与间质性膀胱炎症状指数和问题指数评分高度相关。GUPI对变化有高度反应，男性和女性反应者的评分变化相似。降低7分可稳健预测为治疗应答者（灵敏度100%，特异性76%）。GUPI是一种有效，可靠和反应灵敏的工具，可用于评估男性和女性泌尿生殖器疼痛投诉的症状程度。
To date, separate condition-specific instruments have been used to assess symptom severity in men and women with urologic pain conditions. A single instrument for use in both men and women would be helpful for assessing treatment response in clinical trials and cohort studies involving both genders. We developed the Genitourinary Pain Index (GUPI) by modifying and adding questions to the NIH Chronic Prostatitis Symptom Index. To assess discriminant validity, concurrent validity, and reliability, we administered the GUPI to 1,653 men and 1,403 women in a large managed care population. To assess responsiveness, we administered the GUPI to 47 men and women who completed an NIH-sponsored trial of pelvic floor physical therapy. The GUPI discriminated between men with chronic prostatitis or interstitial cystitis, men with other symptomatic conditions (dysuria, frequency, chronic cystitis), and men with none of these diagnoses (p<0.05). It also discriminated between women with interstitial cystitis, women with incontinence, and women with none of these diagnoses (p<0.05). The GUPI demonstrated good internal consistency within subscale domains, and GUPI scores correlated highly with scores on the Interstitial Cystitis Symptom Index and Problem Index. The GUPI was highly responsive to change, and thechange in score was similar in both male and female responders. A reduction of 7 points robustly predicted being a treatment responder (sensitivity 100%, specificity 76%). The GUPI is a valid, reliable and responsive instrument that can be used to assess the degree of symptoms in both men and women with genitourinary pain complaints.
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影响因子：
6.6
作者：
Sant, GR;Propert, KJ;Nyberg, LM
通讯作者：
Nyberg, LM
影响因子：
6.6
作者：
Clemens, JQ;Meenan, RT;Calhoun, EA
通讯作者：
Calhoun, EA
影响因子：
6.6
作者：
Clemens, J. Quentin;Meenan, Richard T.;Calhoun, Elizabeth A.
通讯作者：
Calhoun, Elizabeth A.
影响因子：
6.6
作者：
Mayer, R;Propert, KJ;Foster, HE
通讯作者：
Foster, HE
影响因子：
2
作者：
FitzGerald, MP;Kenton, KS;Brubaker, L
通讯作者：
Brubaker, L