DENDRITIC SPINE ANOMALIES IN FETAL ALCOHOL SYNDROME
DENDRITIC SPINE ANOMALIES IN FETAL ALCOHOL SYNDROME
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DOI：
10.1055/s-2008-1052472
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发表时间：
1987-08-01
期刊：
影响因子：
1.4
通讯作者：
GALOFRE, E
中科院分区：
文献类型：
--
作者：
FERRER, I;GALOFRE, E
一位慢性酒精中毒母亲所生的4个月大的婴儿，其脑部的神经病理表现为小头畸形、脑岛嘴区域裸露、大脑皮层神经细胞排列紊乱、小脑异常和胶质脑膜异位症。此外，高尔基氏染色显示树突棘数量减少，皮质锥体细胞上具有细长蒂的棘细胞占优势。与新生儿、3个月和4个月对照组的大脑中进行的类似计数相比，该患者V层锥体神经元顶端树突上的DS(学生t检验；p<；0.001)数量显著减少。在这个孩子身上观察到的DS数量的减少和脊椎的异常几何形状表明，儿童可能会发生神经细胞的异常成熟，就像已经证明在啮齿动物中一样，这是妊娠期间长期摄入酒精的结果。
Neuropathological findings in the brain of a 4-month-old child born to a chronic alcoholic mother were microcephaly, uncovered rostral region of the insula, disordered arrangement of nerve cells in the cerebral cortex, cerebellar abnormalities, and glial meningeal heterotopies. In addition, impregnation of neurons by means of the Golgi method showed decreased numbers of dendritic spines and predominance of spines with long, thin pedicles on cortical pyramidal cells. A significant reduction in the number of DS (Student t test; p < 0.001) on the apical dendrites of layer V pyramidal neurons was demonstrated in this patient when compared with similar counts performed in the brain of controls aged newborn, three months and four months. Reduced numbers of DS and abnormal geometry of spines observed in this child suggest that an abnormal maturation of nerve cells may occur in children, like it has also been demonstrated to occur in rodents, as a consequence of chronic ethanol consumption during gestation.