RAPID DEVELOPMENT OF LEARNING-INDUCED RECEPTIVE-FIELD PLASTICITY IN THE AUDITORY-CORTEX
RAPID DEVELOPMENT OF LEARNING-INDUCED RECEPTIVE-FIELD PLASTICITY IN THE AUDITORY-CORTEX
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DOI：
10.1037/0735-7044.107.4.539
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发表时间：
1993-08-01
影响因子：
1.9
通讯作者：
WEINBERGER, NM
中科院分区：
文献类型：
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作者：
EDELINE, JM;PHAM, P;WEINBERGER, NM
经典条件反射在相对较短的训练后(30次实验)在听觉皮质中诱导频率特异性感受场(RF)可塑性，其特征是对条件刺激(CS)频率的反应增加，对其他频率的反应减少，包括训练前的最佳频率(BF)。这项实验决定了这种CS特有的RF可塑性的发展。对豚鼠进行经典的调频条件反射，分别在5、15、30次CS-US(非条件性刺激)配对前后以及训练后1小时测定听觉皮质神经元的感受野。早在前5次训练试验中就观察到了高选择性的射频变化。他们在15次试验后达到顶峰，然后在30次试验和训练后1小时后稳定下来。射频可塑性的快速发展满足了它参与特定联想记忆的神经基础的标准。
Classical conditioning induces frequency-specific receptive field (RF) plasticity in the auditory cortex after relatively brief training (30 trials), characterized by increased response to the frequency of the conditioned stimulus (CS) and decreased responses to other frequencies, including the pretraining best frequency (BF). This experiment determined the development of this CS-specific RF plasticity. Guinea pigs underwent classical conditioning to a tonal frequency, and receptive fields of neurons in the auditory cortex were determined before and after 5, 15, and 30 CS-US (unconditioned stimulus) pairings, as well as 1 hr posttraining. Highly selective RF changes were observed as early as the first 5 training trials. They culminated after 15 trials, then stabilized after 30 trials and 1 hr posttraining. The rapid development of RF plasticity satisfies a criterion for its involvement in the neural bases of a specific associative memory.