Hypercholesterolemia and obesity in adult patients with hypopituitarism: A report of a nation-wide survey in Japan
Hypercholesterolemia and obesity in adult patients with hypopituitarism: A report of a nation-wide survey in Japan
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DOI：
10.1507/endocrj.50.759
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发表时间：
2003-12-01
影响因子：
2
通讯作者：
Kato, Y
中科院分区：
文献类型：
--
作者：
Murakami, Y;Kato, Y
甲状旁腺功能减退的成年患者中，血脂异常和肥胖是很常见的。根据全国成人垂体功能减退调查数据库，分析了1272例日本成年甲状腺功能减退患者中年龄、性别和激素缺乏对高胆固醇血症和肥胖的可能影响。在接受常规激素替代治疗的患者中，30.5%的男性和40.7%的女性被认为是高胆固醇血症。在单变量分析中，高胆固醇血症在女性、老年、未经治疗的Gn缺乏组和TSH缺乏组中更为普遍。多因素分析显示，女性性别、年龄>40岁、TSH缺乏是高胆固醇血症的独立危险因素。肥胖(身体质量指数(BMI)大于或等于25公斤/米(2))在男性、TSH缺乏和ADH缺乏的人群中更为普遍。在最年轻的人群中，重度肥胖(BMI大于或等于30)的患病率很高。这些发现表明，高胆固醇血症和肥胖在不同年龄和性别的日本成年垂体功能减退症患者中普遍存在。甲状腺激素替代不足和促性腺激素缺乏症可能导致高胆固醇血症。相比之下，下丘脑功能障碍和激素缺乏可能在这些患者的肥胖中起作用。
Dyslipidemia and obesity are common in adult patients with hypopituitarism. Possible contributions of age, sex and hormone deficiencies to hypercholesterolemia and obesity in adult hypopituitary patients were analyzed in 1, 272 Japanese cases based on a database of a national survey on adult hypopituitarism. In patients on routine hormone replacement therapy, 30.5% of male and 40.7% of female subjects were considered hypercholesterolemic. In univariate analysis, hypercholesterolemia was more prevalent in female, aged, untreated Gn-deficient and TSH-deficient groups. In multivariate analysis, sex of female, age older than 40 yr and TSH deficiency were the independent contributing factors to hypercholesterolemia. Obesity (body mass index (BMI) greater than or equal to25 kg/m(2)) was more prevalent in male, TSH-deficient and ADH-deficient groups. Severe obesity (BMI greater than or equal to30) was observed in high prevalence in the youngest group. These findings suggest that hypercholesterolemia and obesity were prevalent in different age and gender groups in Japanese adult patients with hypopituitarism. Insufficient replacement of thyroid hormone and possibly gonadotropin deficiency might contribute to hypercholesterolemia. In contrast, hypothalamic dysfunction as well as hormone deficiencies might play roles in obesity in these patients.