Stepwise approach to myopathy in systemic disease.
Stepwise approach to myopathy in systemic disease.
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DOI：
10.3389/fneur.2011.00049
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发表时间：
2011-01-01
影响因子：
3.4
通讯作者：
Chawla, Jasvinder
中科院分区：
文献类型：
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作者：
Chawla, Jasvinder
肌肉疾病可以构成获得性和遗传性疾病的各种各样的。全身性疾病中的肌病由几种不同的疾病过程引起，包括内分泌、炎症、副肿瘤、感染、药物和毒素诱导的、危重病肌病、代谢性肌病和伴有其他全身性疾病的肌病。全身性肌病患者常表现为急性或亚急性。另一方面，家族性肌病或营养不良通常以慢性方式存在，但代谢性肌病除外，代谢性肌病的症状有时会急性加重。大多数炎性肌病可能与恶性病变有偶然联系;发病率似乎仅在皮肌炎患者中特别增加。在处理与全身性疾病相关的肌病时，重点将放在后天原因上。管理超出了本章的范围。预后是基于潜在的原因，大多数情况下，预后良好。为了接近怀疑患有全身性疾病的肌病的患者，采用逐步方法。
Muscle diseases can constitute a large variety of both acquired and hereditary disorders. Myopathies in systemic disease results from several different disease processes including endocrine, inflammatory, paraneoplastic, infectious, drug- and toxin-induced, critical illness myopathy, metabolic, and myopathies with other systemic disorders. Patients with systemic myopathies often present acutely or sub acutely. On the other hand, familial myopathies or dystrophies generally present in a chronic fashion with exceptions of metabolic myopathies where symptoms on occasion can be precipitated acutely. Most of the inflammatory myopathies can have a chance association with malignant lesions; the incidence appears to be specifically increased only in patients with dermatomyositis. In dealing with myopathies associated with systemic illnesses, the focus will be on the acquired causes. Management is beyond the scope of this chapter. Prognosis is based upon the underlying cause and, most of the time, carries a good prognosis. In order to approach a patient with suspected myopathy from systemic disease, a stepwise approach is utilized.