Sodium sensitivity in normotensive and borderline hypertensive humans.
Sodium sensitivity in normotensive and borderline hypertensive humans.
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DOI：
10.1097/00000441-198804000-00025
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发表时间：
1988-04
期刊：
影响因子：
--
通讯作者：
J. Sullivan;R. Prewitt;T. Ratts
中科院分区：
文献类型：
--
作者：
J. Sullivan;R. Prewitt;T. Ratts
研究了92例正常高血压患者和65例边缘性高血压患者对钠消耗和钠补充的反应。交界性高血压的特点是血压、体重、心排血量、红细胞压积、结膜毛细血管和小静脉密度明显升高。钠敏感性被定义为在钠补充期间平均动脉血压升高超过5%。黑人的钠敏感性高于白人，高血压患者的钠敏感性高于正常血压患者。钠敏感个体的特点是前臂血管阻力明显增加，血浆肾素活性和醛固酮浓度降低。这些变化与在达尔盐敏感大鼠中报道的相似之处表明对钠的反应有遗传基础。
The responses to sodium depletion and repletion were studied in subgroups of 92 normotensive and 65 borderline hypertensive individuals. The borderline hypertensives were characterized by significantly higher blood pressure, weight, cardiac output, hematocrit and decreased density of conjunctival capillaries and venules. Sodium-sensitivity was defined as an increase in mean arterial blood pressure exceeding 5% during sodium repletion. The prevalence of sodium-sensitivity was higher in blacks than in whites and greater in hypertensives than in normotensives. Sodium-sensitive individuals were characterized by significantly increased forearm vascular resistance and decreased plasma renin activity and aldosterone concentration. The resemblance of these changes to those reported in the Dahl salt-sensitive rat suggests a genetic basis for the response to sodium.