Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
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DOI：
10.1111/j.1469-7610.2008.01909.x
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发表时间：
2008-10-01
影响因子：
7.6
通讯作者：
Petronis, Arturas
中科院分区：
文献类型：
--
作者：
Mill, Jonathan;Petronis, Arturas
注意力缺陷多动障碍（ADHD）是一种常见的儿童神经行为障碍，其特征是发育不适当的注意力不集中、冲动和多动。作为大多数精神病表型的标准，传统的病因学研究主要集中在遗传和环境因素之间的相互作用。很可能是表观遗传因素，不依赖于DNA序列基因组功能的可遗传但可逆的变化也是重要的。众所周知，表观遗传过程可以在暴露于一系列外部因素后诱导，从而提供了一种环境可以导致表型长期改变的机制。在这篇文章中，我们假设，表观遗传失调可能介导的早期发展的环境侮辱和ADHD之间观察到的关联。我们认为，了解特定环境病原体与ADHD风险增加相关的表观遗传过程可能为预防和治疗干预提供新的可能性。
Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental factors. It is likely that epigenetic factors, i.e., heritable, but reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. In this article we hypothesise that epigenetic dysregulation may mediate the association observed between early-development environmental insults and ADHD. We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention.