Infusion of cytomegalovirus specific cytotoxic T lymphocytes from a sero-negative donor can facilitate resolution of infection and immune reconstitution.
Infusion of cytomegalovirus specific cytotoxic T lymphocytes from a sero-negative donor can facilitate resolution of infection and immune reconstitution.
复制标题
输注来自血清阴性供体的巨细胞病毒特异性细胞毒性T淋巴细胞可以促进感染的解决和免疫重建。
DOI：
10.1097/inf.0b013e318182026f
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Lucas,Kenneth
中科院分区：
文献类型：
--
作者：
Horn,Biljana;Bao,Lei;Dunham,Kimberly;Stamer,Mindy;Adler,Stuart;Cowan,Morton;Lucas,Kenneth
我们报告了一例治疗难治性巨细胞病毒（CMV）感染的干细胞移植患者，他接受了来自血清阴性干细胞供体的CMV特异性T细胞。该供者接受了Towne株巨细胞病毒疫苗，并使用pp65重叠肽脉冲单核细胞扩增T细胞。CTL输注后CMV DNA减少，CMV特异性细胞毒性增加。该策略可用于类似情况或移植后持续病毒血症。
We report a stem cell transplant patient with a therapy-refractory cytomegalovirus (CMV) infection who received CMV-specific T cells from his sero-negative stem cell donor. This donor received the Towne strain CMV vaccine, and T cells were expanded using monocytes pulsed with pp65 overlapping peptides. CMV DNA decreased after the CTL infusion, and CMV-specific cytotoxicity increased. This strategy could be implemented in similar situations or with persistent viremia post-transplant.