Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3.
Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3.
复制标题
使用小鼠单克隆抗体对DR3特异的小分子量（β）亚基的HLA-DR同型决定因素的直接证明。
DOI：
10.1084/jem.156.1.104
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发表时间：
1982-07-01
影响因子：
15.3
通讯作者：
Wank, R
中科院分区：
文献类型：
--
作者：
Johnson, J P;Meo, T;Riethmuller, G;Schendel, D J;Wank, R
描述了一种抗人B细胞表面抗原的鼠单克隆抗体，其具有HLA-DR的特征。检测到的抗原与HLA紧密连锁，并与同种异体抗原HLA-Dw/DR 3相关。还观察到与一部分Dw/DRw 6细胞的反应性。该抗体识别的决定簇已显示存在于HLA-DR抗原的较小分子量β亚基上。
A murine monoclonal antibody directed against a human B cell surface antigen with the characteristics of HLA-DR is described. The antigen detected is tightly linked to HLA and is correlated with the alloantigen HLA-Dw/DR3. Reactivity with a fraction of Dw/DRw6 cells is also observed. The determinant recognized by this antibody has been shown to be present on the smaller molecular weight β subunit of the HLA-DR antigen.