Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function.
Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function.
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DOI：
10.1161/circulationaha.111.060368
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发表时间：
2012-08-28
期刊：
影响因子：
37.8
通讯作者：
Newgard CB
中科院分区：
文献类型：
--
作者：
Shah SH;Kraus WE;Newgard CB
心血管疾病（CVD）是全世界死亡的主要原因，但其分子病因学仍知之甚少，部分原因是遗传和环境因素共同作用导致其发展缓慢。鉴于 CVD 的复杂性，对比遗传标记更“接近”疾病的过程进行分子分析可能在揭示 CVD 的“形式”（具有临床潜力的新型生物标记物）和“功能”（疾病发展机制）方面具有巨大的前景。 CVD 通常与能量稳态和代谢紊乱有关，包括肥胖、胰岛素抵抗和糖尿病。几十年来，人们已经认识到心血管疾病与某些循环脂质（例如胆固醇和甘油三酯）之间的密切关系。然而，除了这些明确的关联之外，代谢失调与 CVD 之间的其他联系很可能仍有待发现，并且作为推论，可以识别新的代谢物特征，从而增强风险预测模型。综合代谢分析或“代谢组学”越来越多地应用于 CVD，导致最近的发现具有形式和功能意义。在这里，我们回顾一下这个快速扩张领域的最新进展。
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, but their molecular etiology remains poorly understood, in part because they develop slowly as a result of a mixture of genetic and environmental factors. Given the complex nature of CVD, molecular profiling of processes more “proximal” to the disease than genetic markers may have great promise in revealing both “form”(novel biomarkers with clinical potential) and “function”(mechanisms of disease development) of CVD. CVD is often associated with conditions of perturbed energy homeostasis and metabolism, including obesity, insulin resistance, and diabetes. The strong relationship between CVD and certain circulating lipids such as cholesterol and triglycerides has been recognized for decades. However, beyond these well-established associations, there is a strong possibility that other links between metabolic dysregulation and CVD remain to be discovered, and as a corollary, that new metabolite signatures can be identified that enhance risk prediction models. Comprehensive metabolic profiling, or “metabolomics” is increasingly being applied to CVD, leading to recent discoveries with both form and function implications. Here we review recent progress in this rapidly expanding area.