Influence of menstrual cycle on muscle glycogen utilization during high-intensity intermittent exercise until exhaustion in healthy women
Influence of menstrual cycle on muscle glycogen utilization during high-intensity intermittent exercise until exhaustion in healthy women
复制标题
健康女性高强度间歇运动至力竭期间月经周期对肌糖原利用的影响
DOI：
10.1139/apnm-2021-0532
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sakamaki-Sunaga Mikako
中科院分区：
文献类型：
--
作者：
Matsuda Tomoka;Takahashi Hideyuki;Nakamura Mariko;Kanno Moe;Ogata Hazuki;Ishikawa Akira;Yamada Mizuki;Kamemoto Kayoko;Sakamaki-Sunaga Mikako
本研究调查了习惯锻炼的健康女性在高强度间歇运动直至筋疲力尽的过程中，月经周期对肌糖原和循环底物的影响。11名有规律月经周期的女性总共完成了三项测试，包括月经周期的卵泡早期(E-FP)、卵泡晚期(L-FP)和黄体期(LP)。在每个测试日进行高强度间歇运动，直到筋疲力尽。运动前(运动前)和运动后即刻(运动后)分别测定肌糖原浓度、雌二醇、孕酮、血糖、乳酸、游离脂肪酸(FFA)和胰岛素浓度。大腿肌糖原浓度在月经周期前后无显著差异(P=0.57)。L-FP组运动后肌糖原下降量(59.0±112.4 mm)显著大于E-FP组(48.3±14.4)mm(P<0.05)。尽管如此，E-FP、L-FP和LP的血糖、血乳酸、血清FFA、血清胰岛素浓度和运动到力竭的时间是相似的。研究结果表明，尽管运动时间不会随着月经周期的变化而变化，但在有习惯性运动的女性中，月经周期会影响高强度间歇运动期间肌糖原的利用，直到筋疲力尽为止。注意：本研究使用13C-磁共振波谱比较了高强度间歇运动直到筋疲力尽期间，肌糖原浓度在月经周期中的变化。我们的结果强调了健康女性在高强度间歇运动期间月经周期对肌糖原的影响。
The present study investigated the effects of the menstrual cycle on muscle glycogen and circulating substrates during high-intensity intermittent exercise until exhaustion in healthy women who habitually exercised. In total, 11 women with regular menstrual cycles completed three tests, which comprised the early follicular phase (E-FP), late follicular phase (L-FP), and luteal phase (LP) of the menstrual cycle. High-intensity intermittent exercise until exhaustion was performed on each test day. Evaluation of muscle glycogen concentration by13C-magnetic resonance spectroscopy and measurement of estradiol, progesterone, blood glucose, lactate, free fatty acids (FFA), and insulin concentrations were conducted before exercise (Pre) and immediately after exercise (Post). Muscle glycogen concentrations from thigh muscles at Pre and Post were not significantly different between menstrual cycle phases (P= 0.57). Muscle glycogen decreases by exercise were significantly greater in L-FP (59.0 ± 12.4 mM) than in E-FP (48.3 ± 14.4 mM,P< 0.05). Nonetheless, blood glucose, blood lactate, serum FFA, serum insulin concentrations, and exercise time until exhaustion in E-FP, L-FP, and LP were similar. The study results suggest that although exercise time does not change according to the menstrual cycle, the menstrual cycle influences muscle glycogen utilization during high-intensity intermittent exercise until exhaustion in women with habitual exercise activity.Novelty:This study compared changes in muscle glycogen concentration across the menstrual cycle during high-intensity intermittent exercise until exhaustion using13C-magnetic resonance spectroscopy.Our results highlight the influence of the menstrual cycle on muscle glycogen during high-intensity intermittent exercise in healthy women.