Necroptosis: A novel therapeutic target for glioblastoma
Necroptosis: A novel therapeutic target for glioblastoma
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DOI：
10.1016/j.mehy.2010.10.037
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发表时间：
2011-03-01
影响因子：
4.7
通讯作者：
Koussougbo, Koku Sossou
中科院分区：
文献类型：
--
作者：
Jiang, Yu-Gang;Peng, Yong;Koussougbo, Koku Sossou
胶质母细胞瘤或多形性胶质母细胞瘤是临床上最常见和最恶性的脑肿瘤。尽管进行了最佳和早期的治疗，但GBM患者的预期寿命仍然很低。细胞凋亡功能障碍被认为是GBM肿瘤发生、增殖和对化疗、放疗耐药的基础。尽管基底膜在凋亡过程中有缺陷，但病理和放射学观察几乎总是在基底膜内发现明显的坏死灶。坏死可能与基底膜的增殖、血管生成和侵袭有关。然而，各种治疗方法引起的肿瘤细胞坏死具有潜在的治疗价值。就在最近，坏死性细胞死亡被认为是一个受调控的过程，就像细胞凋亡一样，被称为坏死性下垂或程序性坏死。诱导细胞凋亡在治疗基底膜方面没有取得任何显着成果，主要是因为肿瘤细胞具有抗凋亡作用。我们可能通过调节GBM的坏死下垂来达到更好的效果，从而绕过细胞的凋亡抵抗。尽管参与GBM坏死性下垂的具体分子途径尚不清楚，治疗诱导的坏死性下垂对GBM的影响还需要更多的研究来证实，但这为我们治疗GBM提供了新的方向。(C)2010爱思唯尔有限公司。保留所有权利。
Glioblastoma or glioblastoma multiforme (GBM) is the most encountered and malignant form of brain tumors in clinical practice. In spite of optimal and early treatment, the life expectancy of patients with GBM remains poor. It is believed that dysfunction of apoptosis underlies GBM tumorigenesis, proliferation and resistance to chemotherapy and radiotherapy. Although GBM is defective in apoptotic process, pathologic and radiologic observations almost always reveal obvious necrosis foci within GBM. Necrosis seems to be related with GBM proliferation, angiogenesis and invasion. However, tumor cell necrosis induced by various therapies has a potential therapeutic value. Just recently, necrotic cell death is considered as a regulated and controlled process, like apoptosis, termed necroptosis or programmed necrosis. Induction of apoptosis has not made any significant achievements in the treatment of GBM mainly because the tumor cells are apoptosis-resistant. We may achieve a better result by modulating the necroptosis of GBM thus circumvent the apoptosis resistance. Albeit specific molecular pathways involved in GBM necroptosis is not clear and much more studies are needed to confirm the effects of therapy-induced necroptosis on GBM, it provides us with a new direction in the treatment of GBM. (C) 2010 Elsevier Ltd. All rights reserved.