MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas
MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas
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DOI：
10.1111/j.1365-2141.2007.06680.x
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发表时间：
2007-08-01
影响因子：
6.5
通讯作者：
Banham, Alison H.
中科院分区：
文献类型：
--
作者：
Liggins, Amanda P.;Cooper, Christopher D. O.;Banham, Alison H.
OX-TES-4抗原最初在50%的弥漫性大B细胞淋巴瘤（DLBCL）患者中引起抗体应答，但在对照受试者中没有。OX-TES-4由位于染色体Xq22.3的新基因MORC 4编码。MORC 4蛋白含有HATPase-c结构域、CW锌指基序、核定位信号和核基质结合结构域以及卷曲螺旋区。MORC 4 mRNA在正常组织中广泛低水平表达，在胎盘和睾丸中表达水平最高。与生发中心来源的DLBCL细胞系和正常B细胞相比，非生发中心来源的DLBCL和霍奇金淋巴瘤细胞系中的mRNA水平增加。19例DLBCL患者（66%）的MORC 4 mRNA表达水平显著高于正常B细胞（P = 0.0031）。MORC 4的差异表达将该分子鉴定为潜在的淋巴瘤生物标志物，其过表达可能有助于DLBCL患者亚组对MORC 4的免疫识别。
The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.