Adhesive phase separation at the dentin interface under wet bonding conditions
Adhesive phase separation at the dentin interface under wet bonding conditions
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DOI：
10.1002/jbm.10364
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发表时间：
2002-12-05
期刊：
影响因子：
--
通讯作者：
Wang, Y
中科院分区：
文献类型：
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作者：
Spencer, P;Wang, Y
在体内条件下，对留在牙齿上的水量几乎没有控制，因此，存在使牙本质表面如此潮湿的危险，使得粘结树脂经历物理分离成疏水相和富水相。本研究的目的是研究相分离在2，2-双[4-（2-羟基-3-甲基丙烯酰氧基-丙氧基）-苯基]丙烷（BisGMA）为基础的胶粘剂使用分子微观分析和检查的效果相分离的结构特征的混合层。将具有/不具有乙醇的模型BisGMA/ HEMA（甲基丙烯酸羟乙酯）混合物和商业BisGMA基粘合剂（Single Bond）与水以0至50体积%的浓度组合。使用浊点测量检测BisGMA/HEMA/水混合物中的宏观相分离。与这些测量平行，将BisGMA/ HEMA和粘合剂/水混合物流延成膜并聚合。使用共焦拉曼显微光谱（CRM）从相分离的粘合剂中的不同特征记录分子结构。通过扫描电子显微镜（SEM）和CRM映射跨牙本质/粘合剂界面分析使用Single Bond处理的人牙本质标本。具有乙醇的模型BisGMA/ HEMA混合物和基于玉米商业BisGMA的粘合剂在类似于25体积%水时经历相分离。从相分离的粘合剂收集的拉曼光谱表明颗粒和周围基质材料的组成分别主要是BisGMA和HEMA。扫描电镜分析显示，在与牙本质的粘接界面处存在大量的孔隙。牙本质/粘合剂界面的显微拉曼光谱分析表明，BisGMA组分的贡献在第一微米内减少了近50%。与光谱数据相印证的形态学结果表明，作为粘合剂相分离的结果，混合层不是不可渗透的三维胶原/聚合物网络，而是以分布在亲水性富含HEMA的基质中的疏水性富含BisGMA的颗粒为特征的多孔网。(C)2002 Wiley Periodicals，Inc.
Under in vivo conditions, there is little control over the amount of water left on the tooth and, thus, there is the danger of leaving the dentin surface so wet that the bonding resin undergoes physical separation into hydrophobic and hydrophilic-rich phases. The purpose of this study was to investigate phase separation in 2,2-bis[4(2hydroxy-3-methacryloyloxy-propyloxy)-phenyl] propane (BisGMA)-based adhesive using molecular microanalysis and to examine the effect of phase separation on the structural characteristics of the hybrid layer. Model BisGMA/ HEMA (hydroxyethl methacrylate) mixtures with/without ethanol and commercial BisGMA-based adhesive (Single Bond) were combined with water at concentrations from 0 to 50 vol%. Macrophase separation in the BisGMA/HEMA/ water mixtures was detected using cloud point measurements. In parallel with these measurements, the BisGMA/ HEMA and adhesive/water mixtures were cast as films and polymerized. Molecular structure was recorded from the distinct features in the phase-separated adhesive using confocal Raman microspectroscopy (CRM). Human dentin specimens treated with Single Bond were analyzed with scanning electron microscopy (SEM) and CRM mapping across the dentin/adhesive interface. The model BisGMA/ HEMA mixtures with ethanol and the corn mercial BisGMA-based adhesive experienced phase separation at similar to25 vol% water. Raman spectra collected from the phase-separated adhesive indicated that the composition of the particles and surrounding matrix material was primarily BisGMA and HEMA, respectively. Based on SEM analysis, there was substantial porosity at the adhesive interface with dentin. Micro-Raman spectral analysis of the dentin/adhesive interface indicates that the contribution from the BisGMA component decreases by nearly 50% within the first micrometer. The morphologic results in corroboration with the spectroscopic data suggest that as a result of adhesive phase separation the hybrid layer is not an impervious 3-dimensional collagen/polymer network but a porous web characterized by hydrophobic BisGMA-rich particles distributed in a hydrophilic HEMA-rich matrix. (C) 2002 Wiley Periodicals, Inc.