Advanced Bioinks for 3D Printing: A Materials Science Perspective
Advanced Bioinks for 3D Printing: A Materials Science Perspective
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DOI：
10.1007/s10439-016-1638-y
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发表时间：
2016-06-01
影响因子：
3.8
通讯作者：
Gaharwar, Akhilesh K.
中科院分区：
文献类型：
--
作者：
Chimene, David;Lennox, Kimberly K.;Gaharwar, Akhilesh K.
用于3D打印的先进生物墨水是合理设计的材料，旨在改善打印支架的功能，超越传统的“生物制造窗口”范式。虽然生物制造窗口范例需要在制造的适用性和容纳封装细胞的能力之间进行折衷，但先进生物墨水的最新发展已经导致了一系列生物制造平台的改进设计，而没有这种折衷。这导致了具有高打印保真度、剪切稀化特性的新一代生物墨水，以及具有高机械强度、高细胞相容性和调节细胞功能的能力的交联支架。在这篇综述中，我们描述了一些有前途的战略正在追求实现这些目标，包括多材料，互穿网络，纳米复合材料，和超分子生物墨水。我们还概述了先进生物墨水合成和生物制造的当前和新兴趋势，并评估了这些新型生物材料在临床应用中的潜在应用。
Advanced bioinks for 3D printing are rationally designed materials intended to improve the functionality of printed scaffolds outside the traditional paradigm of the "biofabrication window". While the biofabrication window paradigm necessitates compromise between suitability for fabrication and ability to accommodate encapsulated cells, recent developments in advanced bioinks have resulted in improved designs for a range of biofabrication platforms without this tradeoff. This has resulted in a new generation of bioinks with high print fidelity, shear-thinning characteristics, and crosslinked scaffolds with high mechanical strength, high cytocompatibility, and the ability to modulate cellular functions. In this review, we describe some of the promising strategies being pursued to achieve these goals, including multimaterial, interpenetrating network, nanocomposite, and supramolecular bioinks. We also provide an overview of current and emerging trends in advanced bioink synthesis and biofabrication, and evaluate the potential applications of these novel biomaterials to clinical use.