Circadian system - A novel diagnostic and therapeutic target in Parkinson's disease?
Circadian system - A novel diagnostic and therapeutic target in Parkinson's disease?
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DOI：
10.1002/mds.26509
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Willis GL
中科院分区：
文献类型：
--
作者：
Videnovic A;Willis GL
昼夜节律系统调节人体的生物节律。昼夜节律系统在神经系统疾病中的作用是一个吸引科学界越来越多兴趣的主题。这在一定程度上是由于新出现的证据表明帕金森病 (PD) 等疾病是多因素造成的，许多特征表现出昼夜波动，从而表明昼夜节律的参与。虽然帕金森病中波动性运动和非运动表现的重要性已得到广泛认可，但昼夜节律系统的作用直到最近才受到关注。有人提出，干预昼夜节律功能提供了一条新的研究途径，可以采取新的策略来改善对症治疗和减缓进行性退行性过程，以减轻帕金森病的负担。在这篇手稿中，我们回顾了描述帕金森病现有昼夜节律研究及其实验模型的文献。
The circadian system regulates biological rhythmicity in the human body. The role of the circadian system in neurological disorders is a theme that is attracting an increasing amount of interest from the scientific community. This has arisen, in part, from emerging evidence that disorders such as Parkinson’s disease (PD) are multifactorial with many features exhibiting diurnal fluctuations, thereby suggestive of circadian involvement. While the importance of fluctuating motor and non-motor manifestations in PD have been well acknowledged, the role of the circadian system has received little attention until recently. It is proposed that intervening with circadian function provides a novel research avenue down which new strategies for improving symptomatic treatment and slowing of the progressive degenerative process can be approached to lessen the burden of PD. In this manuscript we review the literature describing existing circadian research in PD and its’ experimental models.