Metabolic syndrome as a risk factor for high-ocular tension
Metabolic syndrome as a risk factor for high-ocular tension
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DOI：
10.1038/ijo.2010.32
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发表时间：
2010-07-01
影响因子：
4.9
通讯作者：
Kojima, T.
中科院分区：
文献类型：
--
作者：
Imai, K.;Hamaguchi, M.;Kojima, T.
目的：探讨代谢综合征与眼压的关系。方法：在某综合医院健康体检项目中进行观察性研究。这项研究涉及14003名表面上健康的日本男性和女性，年龄在18-83岁之间，平均眼压为14.8(3.0)毫米汞柱。用非接触式眼压计测量眼压。高眼压定义为无视盘异常或接受任何抗青光眼治疗的眼压和眼压为21毫米汞柱。修订的国家胆固醇教育计划成人治疗小组III(RATPIII)的修订标准、国际糖尿病联合会的新定义和日本肥胖研究协会的定义被用来描述代谢综合征。结果：在男性和女性受试者中，平均眼压和高眼压的患病率随着代谢综合征成分的增加而升高。Logistic回归分析显示，男性(调整优势比：2.0[95%可信区间，1.43~2.78]和0.63[95%可信区间，0.54~0.73])和女性(调整优势比：7.09[95%可信区间，3.74~13.43]和0.67[95%可信区间，0.53~0.87])与高眼压呈正相关，最高体温与高眼压呈负相关。5种代谢综合征成分中有3种(空腹血糖、血压和甘油三酯)与高眼压有关。结论：代谢综合征是高眼压的危险因素。《国际肥胖杂志》(2010年)341209-1217年；DOI：10.1038/ijo.2010.32；2010年2月16日在线发表
Objective: To investigate the relationship between the metabolic syndrome and intraocular pressure (IOP).Methods: An observational study was conducted in a medical health checkup program at a general hospital. This study involved 14 003 apparently healthy Japanese men and women, 18-83 years of age, with a mean IOP of 14.8 (3.0) mmHg. IOP was examined by noncontact tonometer. High-ocular tension was defined as IOP > 21 mm Hg without optic-disc abnormalities or history of receiving any anti-glaucoma therapy. Modified criteria of the revised National Cholesterol Education Program Adult Treatment Panel III (rATPIII), the new International Diabetes Federation definition, and the Japan Society for The Study of Obesity definition were used to characterize the metabolic syndrome. Air temperature was assessed from the Gifu Meteorological Observatory, Gifu, Japan.Results: In the male and female subjects, mean IOP and the prevalence of high-ocular tension became high in direct correlation with the increased number of metabolic syndrome components. To analyze by logistic regression, the metabolic syndrome defined by rATPIII was positively and maximum temperature was negatively correlated with high-ocular tension in males (adjusted odds ratio: 2.0 [95% confidence interval, CI, 1.43-2.78] and 0.63 [ 95% CI, 0.54-0.73], respectively) and in females (adjusted odds ratio: 7.09 [ 95% CI, 3.74-13.43] and 0.67 [ 95% CI, 0.53-0.87], respectively). Three of five metabolic syndrome components (fasting plasma glucose, blood pressure, and triglycerides) were related to high-ocular tension.Conclusion: The metabolic syndrome is a risk factor for high-ocular tension. International Journal of Obesity (2010) 34, 1209-1217; doi:10.1038/ijo.2010.32; published online 16 February 2010