RELATION OF CAFFEINE INTAKE DURING PREGNANCY TO INTRAUTERINE GROWTH-RETARDATION AND PRETERM BIRTH
RELATION OF CAFFEINE INTAKE DURING PREGNANCY TO INTRAUTERINE GROWTH-RETARDATION AND PRETERM BIRTH
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DOI：
10.1093/oxfordjournals.aje.a116763
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发表时间：
1993-05-01
影响因子：
5
通讯作者：
BEAULACBAILLARGEON, L
中科院分区：
文献类型：
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作者：
FORTIER, I;MARCOUX, S;BEAULACBAILLARGEON, L
怀孕期间摄入咖啡因是否与宫内发育迟缓、低出生体重和早产有关仍不清楚。这项以人群为基础的研究的目的是评估这些关联，并评估咖啡因摄入量和吸烟之间的相互作用。研究参与者(n=7,025)是居住在加拿大魁北克市及其周边地区的妇女，她们在1989年1月至1989年10月期间生下了一名独生子女新生儿。分娩时的孕周、怀孕期间的咖啡因摄入量(咖啡、茶、巧克力和可乐)以及几个潜在的混杂因素在分娩后几周通过电话获得。出生体重是从出生证明中提取出来的。摄入咖啡因会增加胎儿宫内发育迟缓的风险(出生体重低于性别和胎龄的第10个百分位数)。对于平均每日咖啡因摄入量为0-10、11-150、151-300或300毫克的女性，调整后的优势比分别为1.00、1.28(95%可信区间1.04-1.59)、1.42(95%可信区间1.07-1.87)和1.57(95%可信区间1.05-2.33)。然而，咖啡因的摄入量与早产或低出生体重无关。我们得出结论，孕期摄入咖啡因是胎儿宫内发育迟缓的危险因素。
Whether caffeine intake during pregnancy is related to intrauterine growth retardation, low birth weight, and preterm birth remains unclear. The purpose of this population-based study is to assess these associations and to evaluate the interaction between caffeine intake and smoking. The study participants (n = 7,025) were women who lived in Quebec City, Canada, and the surrounding area who gave birth between January 1989 and October 1989 to a singleton liveborn neonate. Information on gestational age at delivery, caffeine intake (coffee, tea, chocolate, and colas) during pregnancy, and several potential confounders was obtained by telephone a few weeks after delivery. Birth weight was abstracted from the birth certificate. Caffeine consumption was associated with an increased risk of intrauterine growth retardation (birth weight less than the 10th percentile for sex and gestational age). For women whose average daily caffeine consumption was 0-10, 11-150, 151-300, or >300 mg, the adjusted odds ratios for delivering a newborn with growth retardation were 1.00, 1.28 (95% confidence interval (CI) 1.04-1.59), 1.42 (95% CI 1.07-1.87), and 1.57 (95% CI 1.05-2.33), respectively. Caffeine intake, however, was not related to preterm delivery or low birth weight. We conclude that caffeine intake during pregnancy is a risk factor for intrauterine growth retardation.