Cochlear implant histopathology.
Cochlear implant histopathology.
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DOI：
10.1016/j.wjorl.2017.12.008
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Ishiyama, Akira
中科院分区：
文献类型：
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作者：
Linthicum, Fred H Jr;Doherty, Joni K;Ishiyama, Akira
显微检查55个连续切片植入颞骨提供了什么是刺激的见解；这些变化都是由于植入物的植入而产生的。神经节细胞体（神经元）是受到刺激的结构（两个实验室报道了神经元数量与性能的反比关系）。通过圆形窗口植入，与耳蜗造口术相比，产生最少的纤维化和新骨。纤维化和新骨不会影响植入物的功能，除非它们在前庭神经管重聚区形成并阻断它；并产生耳蜗积液导致延迟性低音调听力丧失。由于神经元的大小和髓鞘形成的差异，动物模型不能应用于人类。
The microscopic examination of fifty-five serially sectioned implanted temporal bones has provided insight into what is being stimulated; and the changes that are the result of the insertion and presence of the implant. The ganglion cell bodies (neurons) are structures being stimulated (two laboratories have reported an inverse relationship of the number of neurons and performance). Insertion through the round window, verses a cochleostomy, produces the least fibrosis and new bone. Fibrosis and new bone do not affect the implant function unless they form in the scala vestibuli in the region of the ductus reuniens, and, block it; and produce cochlear hydrops resulting in a delayed low tone loss of hearing in hybrid implants. Animal models cannot be applied to humans because of the difference in size and myelination of the neurons.