"Exuberant" neuronal growth after brain damage in adult rats: the essential role of behavioral experience.
"Exuberant" neuronal growth after brain damage in adult rats: the essential role of behavioral experience.
复制标题
成年大鼠脑损伤后“旺盛”的神经元生长：行为体验的重要作用。
DOI：
10.1155/np.1993.193
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Jones,TA
中科院分区：
文献类型：
--
作者：
Schallert,T;Jones,TA
对脑损伤后功能恢复的神经基础的传统研究经常涉及对行为恢复和可能介导恢复的潜在相关神经变化的分析。我们最近采取了一种完全不同的做法。我们没有假设神经变化介导（或允许）行为，而是证明了相反的情况可能是正确的：行为事件对于神经变化的发生是绝对必要的。这些研究，回顾如下，使我们进一步假设，脑损伤可以敏感，或准备，通过生长促进和修剪机制，剩余的神经组织，以便在适当的行为压力的存在下，组织可以彻底改变，以弥补失去的功能。在该方案中，（a）神经事件不仅需要行为经验（使用依赖性），而且（B）即使有广泛的行为经验，除非也存在脑损伤，否则神经变化可能不会启动，以及（c）在脑损伤发生后可能存在敏感期，在此期间，行为经验可以最大限度地修改神经事件。
Traditional investigations of the neural basis of recovery of function after brain damage frequently involve an analysis of behavioral recovery and of potentially related neural changes that might mediate the recovery. We recently have taken a quite different approach. Instead of assuming that the neural changes mediate (or permit) the behavioral, we showed that the opposite can be true: that behavioral events are absolutely necessary for the neural changes to take place/7-9/. These studies, reviewed below, have led us further to hypothesize thatbrain damage can sensitize, or prepare, remaining neural tissue through growth promoting and pruning-like mechanisms so that in the presence of appropriate behavioral pressure, the tissue can bedrastically altered to compensate for lost function. In this scheme,(a) the neural events not only require behavioral experience (use-dependency), but (b) even with extensive behavioral experience, the neural changes may not be initiated unless there is also brain damage, and (c) there may be a sensitive period after the brain damage occurs during which the behavioral experience can maximally modify the neural events.