Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy
Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy
复制标题
胆红素对结直肠癌对伊立替康化疗反应的预测作用
DOI：
10.3748/wjg.v22.i16.4250
复制
发表时间：
2016-04-28
影响因子：
4.3
通讯作者：
Yuan, Xiang-Lin
中科院分区：
文献类型：
--
作者：
Yu, Qian-Qian;Qiu, Hong;Yuan, Xiang-Lin
AIM: To examine the predictive effects of baseline serum bilirubin levels and UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism on response of colorectal cancer to irinotecan-based chemotherapy.METHODS: The present study was based on a prospective multicenter longitudinal trial of Chinese metastatic colorectal cancer (mCRC) patients treated with irinotecan-based chemotherapy (NCT01282658). Baseline serum bilirubin levels, including total bilirubin (TBil) and unconjugated bilirubin (UBil), were measured, and genotyping of UGT1A1*28 polymorphism was performed. Receiver operating characteristic curve (ROC) analysis was used to determine cutoff values of TBil and UBil. The TBil values were categorized into > 13.0 or 4.1 or
