Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates
Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates
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通过易于合成的 2-亚磺酰基环烯基三氟甲磺酸酯的亚砜-镁交换反应生成环庚炔和环辛炔
DOI：
10.1039/c5cc01784j
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Yoshida;S.;Karaki;F.;Uchida;K.;Hosoya;T.
通过容易合成的2-亚磺酰基环烯基三氟甲磺酸酯的亚砜-镁交换反应有效地生成环庚炔和环辛炔。通过该方法生成的各种亲炔体和环炔之间的环加成反应有效地进行，提供了一种简单的方法来制备与七元或八元碳环稠合的各种杂环。
Cycloheptynes and cyclooctynes were efficiently generated via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates. Cycloadditions between various ynophiles and the cycloalkynes generated by this method proceeded efficiently, providing an easy method to prepare a wide range of heterocycles fused with seven- or eight-membered carbocycles.