Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data
Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data
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DOI：
10.1034/j.1600-0749.2003.00047.x
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发表时间：
2003-06-01
期刊：
影响因子：
--
通讯作者：
Garbe, C
中科院分区：
文献类型：
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作者：
Bauer, J;Garbe, C
高加索人群中获得性黑色素细胞痣(MN)是黑色素瘤发生风险的重要标志。全身MN的总数是黑色素瘤最重要的独立危险因素，黑色素瘤的发生风险几乎随着MN数量的增加而线性增加。此外，非典型MN和光化性扁豆蛋白的存在也是黑色素瘤的独立危险因素。非典型葡萄胎综合征的定义应该是存在许多获得性MN和一定数量的非典型MN。获得性MN主要在儿童和青春期发育，在生命的前20年。获得性痣的数量似乎与遗传因素有关，并且存在易患雀斑的家庭。太阳暴露量是导致雀斑发育的最重要的环境风险因素，尤其是在儿童早期。有趣的是，晒伤可能在雀斑的形成中起到一定作用，但似乎并不是必需的，即使是适度的日晒也会促进这一过程。因此，预防雀斑和黑色素瘤的措施应以儿童和青少年为目标。
Acquired melanocytic nevi (MN) in Caucasian populations are important markers for the risk of melanoma development. The total number of MN on the whole body is the most important independent risk factor for melanoma and the risk of melanoma development increases almost linearly with rising numbers of MN. Additionally, the presence of atypical MN and of actinic lentigines are likewise independent risk factors for melanoma. Atypical mole syndrome should be defined by the presence of many acquired MN and a threshold number of atypical MN. Acquired MN develops mainly during childhood and adolescence in the first two decades of life. The number of acquired nevi seems to be related to hereditary factors and nevus-prone families exist. The amount of sun exposure is the most important environmental risk factor for nevus development, particularly in early childhood. Interestingly, sunburns may play a role in nevus development, but seem not to be required, and even moderate sun exposure promotes the process. Therefore, preventive measures for nevus and melanoma development should target young children and adolescents.